Syntheses of two deacetyl-thymosin α1 analogues and their effects on low E-rosette-forming lymphocytes of uraemic patients
Two deacetyl-thymosin α1 analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)21]deacetyl-thymosin α1 and [Phe(4Br)21]deacetyl-thymosin α1, respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic p...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935196000439 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Two deacetyl-thymosin α1 analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)21]deacetyl-thymosin α1 and [Phe(4Br)21]deacetyl-thymosin α1, respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)21deacetyl-thymosin α1, demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α1, but the other analogue, [D-Phe(4Br)21]deacetyl-thymosin α1, showed no restorative effect under the same conditions. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |