Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring
Abstract Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer ri...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56252-8 |
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| _version_ | 1832585567627378688 |
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| author | Yixue Wang Hongru Sun Gen Li Jingxue Xu Siyu Wang Shijie Zhang Tianle Zhou Tianshu Han Changhao Sun Jianqun Ma Xiaoyuan Wang Hang Yin |
| author_facet | Yixue Wang Hongru Sun Gen Li Jingxue Xu Siyu Wang Shijie Zhang Tianle Zhou Tianshu Han Changhao Sun Jianqun Ma Xiaoyuan Wang Hang Yin |
| author_sort | Yixue Wang |
| collection | DOAJ |
| description | Abstract Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. Here, we show that being breastfed, compared with not being breastfed, is associated with a lower risk of oesophageal cancer incidence (HR: 0.83, 95% CI: 0.70–0.98) and mortality (HR: 0.74, 95% CI: 0.61–0.89) in adult offspring. Additionally, it is associated with a reduced impact of smoking in offspring on oesophageal cancer incidence (HR: 0.79, 95% CI: 0.64-0.96) and mortality (HR: 0.73, 95% CI: 0.59-0.91). We subsequently construct a polygenic risk score for oesophageal cancer to explore the influence of genetic factors. Our findings emphasize the importance of breastfeeding, and smoking cessation to prevent oesophageal cancer. |
| format | Article |
| id | doaj-art-62a2bc84744946aa9ff67cd29ee9dc59 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-62a2bc84744946aa9ff67cd29ee9dc592025-01-26T12:41:50ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-025-56252-8Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspringYixue Wang0Hongru Sun1Gen Li2Jingxue Xu3Siyu Wang4Shijie Zhang5Tianle Zhou6Tianshu Han7Changhao Sun8Jianqun Ma9Xiaoyuan Wang10Hang Yin11Department of Thoracic Surgery, Harbin Medical University Cancer HospitalDepartment of Epidemiology, Public Health College, Harbin Medical UniversityDepartment of Radiation Therapy, Harbin Medical University Cancer HospitalDepartment of Thoracic Surgery, Harbin Medical University Cancer HospitalDepartment of Radiation Therapy, Harbin Medical University Cancer HospitalDepartment of Radiation Therapy, Harbin Medical University Cancer HospitalDepartment of Radiation Therapy, Harbin Medical University Cancer HospitalNational Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical UniversityNational Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical UniversityDepartment of Thoracic Surgery, Harbin Medical University Cancer HospitalDepartment of Thoracic Surgery, Harbin Medical University Cancer HospitalDepartment of Radiation Therapy, Harbin Medical University Cancer HospitalAbstract Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. Here, we show that being breastfed, compared with not being breastfed, is associated with a lower risk of oesophageal cancer incidence (HR: 0.83, 95% CI: 0.70–0.98) and mortality (HR: 0.74, 95% CI: 0.61–0.89) in adult offspring. Additionally, it is associated with a reduced impact of smoking in offspring on oesophageal cancer incidence (HR: 0.79, 95% CI: 0.64-0.96) and mortality (HR: 0.73, 95% CI: 0.59-0.91). We subsequently construct a polygenic risk score for oesophageal cancer to explore the influence of genetic factors. Our findings emphasize the importance of breastfeeding, and smoking cessation to prevent oesophageal cancer.https://doi.org/10.1038/s41467-025-56252-8 |
| spellingShingle | Yixue Wang Hongru Sun Gen Li Jingxue Xu Siyu Wang Shijie Zhang Tianle Zhou Tianshu Han Changhao Sun Jianqun Ma Xiaoyuan Wang Hang Yin Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring Nature Communications |
| title | Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| title_full | Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| title_fullStr | Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| title_full_unstemmed | Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| title_short | Impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| title_sort | impact of maternal and offspring smoking and breastfeeding on oesophageal cancer in adult offspring |
| url | https://doi.org/10.1038/s41467-025-56252-8 |
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