Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta.

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta.

The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goats in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of drug resistance, we have generated a highly contiguous genome assemb...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Duncan Berger, Daniel R G Price, Sam Dougan, Dionysis Grigoriadis, Alan Tracey, Nancy Holroyd, Katie Bull, Hannah Rose Vineer, Mike J Glover, Eric R Morgan, Alasdair J Nisbet, Tom N McNeilly, Yvonne Bartley, Neil Sargison, Dave Bartley, Matt Berriman, James A Cotton, Eileen Devaney, Roz Laing, Stephen R Doyle
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-02-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1012820
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta.
by: Young-Jun Choi, et al.
Published: (2017-06-01)

Development and field application of metabarcoding-adapted mt-ND4 markers shows substantial gene flow and varying local pressures on Haemonchus contortus and Teladorsagia circumcincta populations in the UK.
by: Osama Zahid, et al.
Published: (2025-01-01)

Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.
by: Roz Laing, et al.
Published: (2022-06-01)

Motivational Interviewing is “” What Matters: Integrating Motivational Interviewing Spirit and Skills into What Matters to You? Conversations
by: Damara Gutnick MD, et al.
Published: (2025-02-01)

“Do probiotics mitigate GI-induced inflammation and perceived fatigue in athletes? A systematic review”
by: R.P. Kearns, et al.
Published: (2024-12-01)

Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing.
by: Elizabeth Redman, et al.
Published: (2012-02-01)

The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep.
by: Kirsten Hogg, et al.
Published: (2011-01-01)

A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity
by: Matias G. Perez, et al.
Published: (2025-03-01)

Commentary: Uplifting or down the rabbit hole?Central Message
by: Bartley P. Griffith, MD, FACS, FRCS
Published: (2021-06-01)

Childhood Overweight/Obesity amidst Migration, Socioeconomic Factors, and Obesogenic Behaviors: Insights from the Growing Up in New Zealand Study
by: Mehdi Rahimi, et al.
Published: (2023-01-01)

The sweet escape: Are ketones a key player in unlocking healthy aging?
by: Andreia N. Cadar, et al.
Published: (2024-11-01)

Budd-Chiari Syndrome Treated With IVC Stenting With Subsequent Right Hepatic Vein to IVC Retrograde Sharp Recanalization
by: Andrew C. Gordon, et al.
Published: (2025-01-01)

In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol
by: Iain R. Phair, et al.
Published: (2025-03-01)

Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans.
by: Roz Laing, et al.
Published: (2011-01-01)

Internalized stigma mediates the relationship between pelvic pain severity and both depression and anxiety in women with chronic pelvic pain
by: Sarah E. Francis, et al.
Published: (2025-06-01)

Root segmentation of horticultural plants in X-Ray CT images by integrating 2D instance segmentation with 3D point cloud clustering
by: Mary E. Cassity, et al.
Published: (2024-12-01)

Activation of the Nrf2 Pathway by Sulforaphane Improves Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes
by: Heather J. Merchant, et al.
Published: (2025-03-01)

Psychosocial factors that shape patient and carer experiences of dementia diagnosis and treatment: a systematic review of qualitative studies.
by: Frances Bunn, et al.
Published: (2012-10-01)

The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome.
by: Fiona Connolly, et al.
Published: (2014-01-01)

Reduction of tungiasis prevalence, intensity, and morbidity during a two-year long community-based tungiasis control project in a hyperendemic region in Karamoja, Uganda.
by: Hannah McNeilly, et al.
Published: (2025-06-01)

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection.
by: Changwei Chen, et al.
Published: (2021-01-01)

Localization of TRPV3/4 and PIEZO1/2 sensory receptors in murine and human larynges
by: Alexander G. Foote, et al.
Published: (2022-12-01)

Decision-making regarding place of end-of-life care for children with life-limiting and life-threatening conditions: a systematic integrative review
by: Ashleen Crowe, et al.
Published: (2025-01-01)

Preferences for Biologic Treatments: A Discrete Choice Experiment Survey of Canadians with Severe Asthma
by: Dunne JS, et al.
Published: (2025-05-01)

Student and Physician Views of How the Dobbs Decision Affects Training and Practice Location Preferences: Cross-Sectional Questionnaire Study
by: Morgan S Levy, et al.
Published: (2025-01-01)

Perceptions, barriers, and challenges of adopting battery-powered landscape equipment in professional maintenance
by: Kati Kent, et al.
Published: (2025-07-01)

Management of Pulmonary Artery Aneurysms in Pulmonary Hypertension: A Single-Center Review of 3 Cases
by: Talha Ahmed, et al.
Published: (2019-01-01)

The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS).
by: Mick Rae, et al.
Published: (2013-01-01)

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei.
by: Eva Rico, et al.
Published: (2017-03-01)

Timing of Dike and Sill Emplacement in the Inner Aureole of the Alta Stock, Utah Determined by Zircon and Monazite Petrochronology
by: C. J. Beno, et al.
Published: (2025-05-01)

Global estimate of the prevalence of post-traumatic stress disorder among adults living with HIV: a systematic review and meta-analysis
by: Lloyd Goldsamt, et al.
Published: (2020-04-01)

A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes.
by: Victoria Gillan, et al.
Published: (2014-02-01)

Detection of abortifacient agents in domestic ruminants, with a specific focus on Coxiella burnetii [version 2; peer review: 2 approved]
by: Susan Neale, et al.
Published: (2025-06-01)

Towards a learning healthcare community in the Bronx: evaluating the Bridging Research, Accurate Information and Dialogue (BRAID) model
by: Sarah M. McNeilly, et al.
Published: (2025-02-01)

Promoting a foundation of resilience in older adults: pilot trial of a strengths-based positive psychology intervention for chronic low back pain
by: Emily J. Bartley, et al.
Published: (2024-12-01)

Simulating Performance of a Dual Angle Particle Monitor for Atmospheric Particulate Matter
by: Charles D. Litton, et al.
Published: (2021-01-01)

Tick ecology and host-finding efficiency interact to determine disease risk: a model of heartwater dynamics
by: Adam M. Fisher, et al.

Acoustic therapy for allergic rhinitis and chronic rhinosinusitis: modulating microbiome, immunity and well-being
by: Jude Oluwapelumi Alao, et al.
Published: (2025-08-01)

Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities.
by: Tushabe John Vianney, et al.
Published: (2022-08-01)

Improvisation, Blankness and Mesmerism: Mike Leggett and Ian Breakwell’s Sheet and the Two Avant-Gardes
by: Kieran Devaney
Published: (2021-12-01)