The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells
Objective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic effects and therefore, the understanding of the molecular mechanism of nGO toxicity is very important mainly for the n...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-01-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2024-0029 |
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| author | Minchenko Oleksandr Kulish Yuliia V. Viletska Yuliia M. Khita Olena O. Rudnytska Olha V. Kozynkevych Halyna E. Minchenko Dmytro O. |
| author_facet | Minchenko Oleksandr Kulish Yuliia V. Viletska Yuliia M. Khita Olena O. Rudnytska Olha V. Kozynkevych Halyna E. Minchenko Dmytro O. |
| author_sort | Minchenko Oleksandr |
| collection | DOAJ |
| description | Objective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic effects and therefore, the understanding of the molecular mechanism of nGO toxicity is very important mainly for the nanomedicine, especially the cancer therapy. This study aimed to examine the impact of nGO NPs on the expression of genes associated with endoplasmic reticulum (ER) stress, proliferation, and cancerogenesis in both normal human astrocytes and U87MG glioblastoma cells. |
| format | Article |
| id | doaj-art-6299f828db9e43e8b2edc77ee876dee1 |
| institution | OA Journals |
| issn | 1336-0329 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj-art-6299f828db9e43e8b2edc77ee876dee12025-08-20T01:59:21ZengSciendoEndocrine Regulations1336-03292024-01-0158110.2478/enr-2024-0029The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cellsMinchenko Oleksandr0Kulish Yuliia V.1Viletska Yuliia M.2Khita Olena O.3Rudnytska Olha V.4Kozynkevych Halyna E.5Minchenko Dmytro O.61Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, Ukraine2Department of Pediatrics No.1, National Bohomolets Medical University, Kyiv, Ukraine1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv01054, UkraineObjective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic effects and therefore, the understanding of the molecular mechanism of nGO toxicity is very important mainly for the nanomedicine, especially the cancer therapy. This study aimed to examine the impact of nGO NPs on the expression of genes associated with endoplasmic reticulum (ER) stress, proliferation, and cancerogenesis in both normal human astrocytes and U87MG glioblastoma cells.https://doi.org/10.2478/enr-2024-0029nanographene oxidednajb9ddit3edem1idh2mrna expressiongeno-toxicityern1 knockdownnormal human astrocytesglioblastoma cells |
| spellingShingle | Minchenko Oleksandr Kulish Yuliia V. Viletska Yuliia M. Khita Olena O. Rudnytska Olha V. Kozynkevych Halyna E. Minchenko Dmytro O. The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells Endocrine Regulations nanographene oxide dnajb9 ddit3 edem1 idh2 mrna expression geno-toxicity ern1 knockdown normal human astrocytes glioblastoma cells |
| title | The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| title_full | The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| title_fullStr | The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| title_full_unstemmed | The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| title_short | The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| title_sort | expression of dnajb9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells |
| topic | nanographene oxide dnajb9 ddit3 edem1 idh2 mrna expression geno-toxicity ern1 knockdown normal human astrocytes glioblastoma cells |
| url | https://doi.org/10.2478/enr-2024-0029 |
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