Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria
Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent. Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/861296 |
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| author | Moses Temidayo Abiodun Nosakhare J. Iduoriyekemwen Phillip O. Abiodun |
| author_facet | Moses Temidayo Abiodun Nosakhare J. Iduoriyekemwen Phillip O. Abiodun |
| author_sort | Moses Temidayo Abiodun |
| collection | DOAJ |
| description | Background. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent. Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children. Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P=0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m2, significantly lower than 126.9 ± 28.5 mL/min/1.73 m2 in the control group, (P=0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m2 (21.5% versus 5.4%; P=0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r=0.23; P=0.022). Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method. |
| format | Article |
| id | doaj-art-6298ab67f570484fbcab8faa6fcc8ff1 |
| institution | DOAJ |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-6298ab67f570484fbcab8faa6fcc8ff12025-08-20T03:19:29ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/861296861296Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern NigeriaMoses Temidayo Abiodun0Nosakhare J. Iduoriyekemwen1Phillip O. Abiodun2Department of Child Health, University of Benin Teaching Hospital, Benin 300001, NigeriaDepartment of Child Health, University of Benin Teaching Hospital, Benin 300001, NigeriaDepartment of Child Health, University of Benin Teaching Hospital, Benin 300001, NigeriaBackground. Human immunodeficiency virus (HIV) is now a confirmed risk factor for kidney disease with an increased burden in persons of African descent. Method. We measured the serum cystatin C levels of 205 ART-naive, HIV-infected children by an ELISA technique and compared them with the levels of apparently healthy children. Result. The mean ± SD serum cystatin C level of children with HIV infection was 1.01 ± 0.44 mg/L, significantly higher than the mean value in the control group, that is, 0.72 ± 0.20 mg/L (P=0.000). The mean ± SD cystatin C-based estimated GFR of children with HIV infection was 102.7 ± 31.0 mL/min/1.73 m2, significantly lower than 126.9 ± 28.5 mL/min/1.73 m2 in the control group, (P=0.014). A significantly higher proportion of HIV-infected children compared to controls had eGFR < 90 mL/min/1.73 m2 (21.5% versus 5.4%; P=0.00). The prevalence of chronic kidney disease (CKD) among the HIV-infected children was 10.7%. The cystatin C-based eGFR of the HIV-infected children ≥5 years old correlated positively with their CD4 count (r=0.23; P=0.022). Conclusion. There is a high prevalence of CKD among HIV-infected children, requiring regular monitoring of their kidney function using a cystatin C-based method.http://dx.doi.org/10.1155/2012/861296 |
| spellingShingle | Moses Temidayo Abiodun Nosakhare J. Iduoriyekemwen Phillip O. Abiodun Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria International Journal of Nephrology |
| title | Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria |
| title_full | Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria |
| title_fullStr | Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria |
| title_full_unstemmed | Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria |
| title_short | Cystatin C-Based Evaluation of Kidney Function of HIV-Infected Children in Benin City, Southern Nigeria |
| title_sort | cystatin c based evaluation of kidney function of hiv infected children in benin city southern nigeria |
| url | http://dx.doi.org/10.1155/2012/861296 |
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