A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction
Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7515346 |
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| _version_ | 1832548396900024320 |
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| author | Yang Yang Guihuan Liu Qingnan He Jie Shen Linyong Xu Ping Zhu Mingyi Zhao |
| author_facet | Yang Yang Guihuan Liu Qingnan He Jie Shen Linyong Xu Ping Zhu Mingyi Zhao |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Sepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis. |
| format | Article |
| id | doaj-art-6290f4f38c304c1c9c822e7d1edd213d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-6290f4f38c304c1c9c822e7d1edd213d2025-02-03T06:14:10ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/75153467515346A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis PredictionYang Yang0Guihuan Liu1Qingnan He2Jie Shen3Linyong Xu4Ping Zhu5Mingyi Zhao6Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, ChinaDepartment of Biomedical Informatics, School of Life Sciences, Central South University, Changsha, Hunan 410000, ChinaGuangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, ChinaSepsis is a systemic inflammatory response syndrome caused by infection. With high morbidity and mortality of this disease, there is a need to find early effective diagnosis and assessment methods to improve the prognosis of patients. Heparin-binding protein (HBP) is a granular protein derived from polynuclear neutrophils. The biosynthetic HBP in neutrophils is rapidly released under the stimulation of bacteria, resulting in increased vascular permeability and edema. It is reasonable to speculate that the HBP in plasma may serve as a novel diagnostic marker for sepsis, bacterial skin infection, acute bacterial meningitis, leptospirosis, protozoan parasites, and even some noncommunicable diseases. It implies that in the detection and diagnosis of sepsis, it will be possible to make relevant diagnosis through this new indicator in the future. In this review, we summarize the typical biological function of HBP and its latest research progress to provide theoretical basis for clinical prediction and diagnosis of sepsis.http://dx.doi.org/10.1155/2019/7515346 |
| spellingShingle | Yang Yang Guihuan Liu Qingnan He Jie Shen Linyong Xu Ping Zhu Mingyi Zhao A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction Journal of Immunology Research |
| title | A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction |
| title_full | A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction |
| title_fullStr | A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction |
| title_full_unstemmed | A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction |
| title_short | A Promising Candidate: Heparin-Binding Protein Steps onto the Stage of Sepsis Prediction |
| title_sort | promising candidate heparin binding protein steps onto the stage of sepsis prediction |
| url | http://dx.doi.org/10.1155/2019/7515346 |
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