Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.
<h4>Objectives</h4>Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian R...
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2013-01-01
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| author | Joanna E Cobb Darren Plant Edward Flynn Meriem Tadjeddine Philippe Dieudé François Cornélis Lisbeth Ärlestig Solbritt Rantapää Dahlqvist George Goulielmos Dimitrios T Boumpas Prodromos Sidiropoulos Sophine B Krintel Lykke M Ørnbjerg Merete L Hetland Lars Klareskog Thomas Haeupl Andrew Filer Christopher D Buckley Karim Raza Torsten Witte Reinhold E Schmidt Oliver FitzGerald Douglas Veale Stephen Eyre Jane Worthington |
| author_facet | Joanna E Cobb Darren Plant Edward Flynn Meriem Tadjeddine Philippe Dieudé François Cornélis Lisbeth Ärlestig Solbritt Rantapää Dahlqvist George Goulielmos Dimitrios T Boumpas Prodromos Sidiropoulos Sophine B Krintel Lykke M Ørnbjerg Merete L Hetland Lars Klareskog Thomas Haeupl Andrew Filer Christopher D Buckley Karim Raza Torsten Witte Reinhold E Schmidt Oliver FitzGerald Douglas Veale Stephen Eyre Jane Worthington |
| author_sort | Joanna E Cobb |
| collection | DOAJ |
| description | <h4>Objectives</h4>Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.<h4>Methods</h4>A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.<h4>Results</h4>Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)).<h4>Conclusions</h4>This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene. |
| format | Article |
| id | doaj-art-628ccdef86944f8a88af42fb2ef3e519 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-628ccdef86944f8a88af42fb2ef3e5192025-08-20T02:05:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6645610.1371/journal.pone.0066456Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.Joanna E CobbDarren PlantEdward FlynnMeriem TadjeddinePhilippe DieudéFrançois CornélisLisbeth ÄrlestigSolbritt Rantapää DahlqvistGeorge GoulielmosDimitrios T BoumpasProdromos SidiropoulosSophine B KrintelLykke M ØrnbjergMerete L HetlandLars KlareskogThomas HaeuplAndrew FilerChristopher D BuckleyKarim RazaTorsten WitteReinhold E SchmidtOliver FitzGeraldDouglas VealeStephen EyreJane Worthington<h4>Objectives</h4>Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.<h4>Methods</h4>A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.<h4>Results</h4>Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)).<h4>Conclusions</h4>This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066456&type=printable |
| spellingShingle | Joanna E Cobb Darren Plant Edward Flynn Meriem Tadjeddine Philippe Dieudé François Cornélis Lisbeth Ärlestig Solbritt Rantapää Dahlqvist George Goulielmos Dimitrios T Boumpas Prodromos Sidiropoulos Sophine B Krintel Lykke M Ørnbjerg Merete L Hetland Lars Klareskog Thomas Haeupl Andrew Filer Christopher D Buckley Karim Raza Torsten Witte Reinhold E Schmidt Oliver FitzGerald Douglas Veale Stephen Eyre Jane Worthington Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLoS ONE |
| title | Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. |
| title_full | Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. |
| title_fullStr | Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. |
| title_full_unstemmed | Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. |
| title_short | Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. |
| title_sort | identification of the tyrosine protein phosphatase non receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0066456&type=printable |
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