Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis
<b>Background:</b> The present Bayesian network meta-analysis compared the efficacy of intra-articular injections of different molecular weights of hyaluronic acid (HA) in patients with knee osteoarthritis. <b>Methods:</b> In November 2024, the following databases were access...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/1/175 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588975370403840 |
|---|---|
| author | Filippo Migliorini Nicola Maffulli Cornelis Hindriks Nijboer Gaetano Pappalardo Mario Pasurka Marcel Betsch Joshua Kubach |
| author_facet | Filippo Migliorini Nicola Maffulli Cornelis Hindriks Nijboer Gaetano Pappalardo Mario Pasurka Marcel Betsch Joshua Kubach |
| author_sort | Filippo Migliorini |
| collection | DOAJ |
| description | <b>Background:</b> The present Bayesian network meta-analysis compared the efficacy of intra-articular injections of different molecular weights of hyaluronic acid (HA) in patients with knee osteoarthritis. <b>Methods:</b> In November 2024, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. All randomised controlled trials investigating the efficacy of intra-articular HA injections for knee osteoarthritis were accessed. The outcome of interest was to evaluate pain according to the visual analogue scale (VAS). The groups included for comparison were the ultra-high molecular weight (UHMW), high molecular weight (HMW), medium molecular weight (MMW), and low molecular weight (LMW). <b>Results:</b> Data from 9822 patients were collected. The mean age of the patients was 62.1 ± 5.0 years with given comparability at baseline. Different follow-up periods were compared. The longest control period ranged from four to six months, and the UHMW and HMW injections were the interventions associated with the greatest reduction in the VAS. LMW HA was the intervention associated with the lowest decrease in VAS, falling short of the control group. <b>Conclusions:</b> The main findings of the present Bayesian network meta-analysis, with a current level I of evidence, suggests that the UHMW and HMW HA has a beneficial effect on pain at 6 months post intervention in patients with knee osteoarthritis. |
| format | Article |
| id | doaj-art-628b6dc93d214247b98b1fe8652c8087 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-628b6dc93d214247b98b1fe8652c80872025-01-24T13:24:16ZengMDPI AGBiomedicines2227-90592025-01-0113117510.3390/biomedicines13010175Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-AnalysisFilippo Migliorini0Nicola Maffulli1Cornelis Hindriks Nijboer2Gaetano Pappalardo3Mario Pasurka4Marcel Betsch5Joshua Kubach6Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), 39100 Bolzano, ItalyFaculty of Medicine and Psychology, University La Sapienza, 00185 Roma, ItalyDepartment of Life Sciences, Health, and Health Professions, Link Campus University, Via del Casale di San Pio V, 00165 Rome, ItalyDepartment of Orthopaedic Surgery, Oberlinklinik, 14482 Potsdam, GermanyDepartment of Trauma and Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Trauma and Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Trauma and Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, University Hospital Erlangen, 91054 Erlangen, Germany<b>Background:</b> The present Bayesian network meta-analysis compared the efficacy of intra-articular injections of different molecular weights of hyaluronic acid (HA) in patients with knee osteoarthritis. <b>Methods:</b> In November 2024, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. All randomised controlled trials investigating the efficacy of intra-articular HA injections for knee osteoarthritis were accessed. The outcome of interest was to evaluate pain according to the visual analogue scale (VAS). The groups included for comparison were the ultra-high molecular weight (UHMW), high molecular weight (HMW), medium molecular weight (MMW), and low molecular weight (LMW). <b>Results:</b> Data from 9822 patients were collected. The mean age of the patients was 62.1 ± 5.0 years with given comparability at baseline. Different follow-up periods were compared. The longest control period ranged from four to six months, and the UHMW and HMW injections were the interventions associated with the greatest reduction in the VAS. LMW HA was the intervention associated with the lowest decrease in VAS, falling short of the control group. <b>Conclusions:</b> The main findings of the present Bayesian network meta-analysis, with a current level I of evidence, suggests that the UHMW and HMW HA has a beneficial effect on pain at 6 months post intervention in patients with knee osteoarthritis.https://www.mdpi.com/2227-9059/13/1/175kneeosteoarthritishyaluronic acidinjections |
| spellingShingle | Filippo Migliorini Nicola Maffulli Cornelis Hindriks Nijboer Gaetano Pappalardo Mario Pasurka Marcel Betsch Joshua Kubach Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis Biomedicines knee osteoarthritis hyaluronic acid injections |
| title | Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis |
| title_full | Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis |
| title_fullStr | Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis |
| title_full_unstemmed | Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis |
| title_short | Comparison of Different Molecular Weights of Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Level I Bayesian Network Meta-Analysis |
| title_sort | comparison of different molecular weights of intra articular hyaluronic acid injections for knee osteoarthritis a level i bayesian network meta analysis |
| topic | knee osteoarthritis hyaluronic acid injections |
| url | https://www.mdpi.com/2227-9059/13/1/175 |
| work_keys_str_mv | AT filippomigliorini comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT nicolamaffulli comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT cornelishindriksnijboer comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT gaetanopappalardo comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT mariopasurka comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT marcelbetsch comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis AT joshuakubach comparisonofdifferentmolecularweightsofintraarticularhyaluronicacidinjectionsforkneeosteoarthritisalevelibayesiannetworkmetaanalysis |