LncRNA regulation in ischemic stroke and their application prospects
Ischemic stroke is a serious medical event that cannot be predicted in advance and can have long-lasting effects on patients, families, and communities. A deeper understanding of the changes in gene expression and the fundamental molecular mechanisms involved could help address this critical issue....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2026-03-01
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| Series: | Neural Regeneration Research |
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| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00924 |
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| author | Qianqian Chen Xiangyi Xu Shun Li Tianqing Xiong |
| author_facet | Qianqian Chen Xiangyi Xu Shun Li Tianqing Xiong |
| author_sort | Qianqian Chen |
| collection | DOAJ |
| description | Ischemic stroke is a serious medical event that cannot be predicted in advance and can have long-lasting effects on patients, families, and communities. A deeper understanding of the changes in gene expression and the fundamental molecular mechanisms involved could help address this critical issue. In recent years, research into regulatory long non-coding (lnc)RNAs, a diverse group of RNA molecules with regulatory functions, has emerged as a promising direction in the study of cerebral infarction. This review paper aims to provide a comprehensive exploration of the roles of regulatory lncRNAs in cerebral infarction, as well as potential strategies for their application in clinical settings. LncRNAs have the potential to act as “sponges” that attract specific microRNAs, thereby regulating the expression of microRNA target genes. These interactions influence various aspects of ischemic stroke, including reperfusion-induced damage, cell death, immune responses, autophagy, angiogenesis, and the generation of reactive oxygen species. We highlight several regulatory lncRNAs that have been utilized in animal model treatments, including lncRNA NKILA, lncRNA Meg8, and lncRNA H19. Additionally, we discuss lncRNAs that have been used as biomarkers for the diagnosis and prognosis of cerebral infarction, such as lncRNA FOXO3, lncRNA XIST, and lncRNA RMST. The lncRNAs hold potential for genetic-level treatments in patients. However, numerous challenges, including inefficiency, low targeting accuracy, and side effects observed in preliminary studies, indicate the need for thorough investigation. The application of lncRNAs in ischemic stroke presents challenges that require careful and extensive validation. |
| format | Article |
| id | doaj-art-6286e4e0f35d47958668ce9f25ce7376 |
| institution | DOAJ |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2026-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-6286e4e0f35d47958668ce9f25ce73762025-08-20T02:44:23ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582026-03-012131058107310.4103/NRR.NRR-D-24-00924LncRNA regulation in ischemic stroke and their application prospectsQianqian ChenXiangyi XuShun LiTianqing XiongIschemic stroke is a serious medical event that cannot be predicted in advance and can have long-lasting effects on patients, families, and communities. A deeper understanding of the changes in gene expression and the fundamental molecular mechanisms involved could help address this critical issue. In recent years, research into regulatory long non-coding (lnc)RNAs, a diverse group of RNA molecules with regulatory functions, has emerged as a promising direction in the study of cerebral infarction. This review paper aims to provide a comprehensive exploration of the roles of regulatory lncRNAs in cerebral infarction, as well as potential strategies for their application in clinical settings. LncRNAs have the potential to act as “sponges” that attract specific microRNAs, thereby regulating the expression of microRNA target genes. These interactions influence various aspects of ischemic stroke, including reperfusion-induced damage, cell death, immune responses, autophagy, angiogenesis, and the generation of reactive oxygen species. We highlight several regulatory lncRNAs that have been utilized in animal model treatments, including lncRNA NKILA, lncRNA Meg8, and lncRNA H19. Additionally, we discuss lncRNAs that have been used as biomarkers for the diagnosis and prognosis of cerebral infarction, such as lncRNA FOXO3, lncRNA XIST, and lncRNA RMST. The lncRNAs hold potential for genetic-level treatments in patients. However, numerous challenges, including inefficiency, low targeting accuracy, and side effects observed in preliminary studies, indicate the need for thorough investigation. The application of lncRNAs in ischemic stroke presents challenges that require careful and extensive validation.https://journals.lww.com/10.4103/NRR.NRR-D-24-00924adeno-associated virusangiogenesisautophagygene therapyischemic strokelong non-coding rnasneuroinflammationoxidative stresspathophysiological mechanismstroke |
| spellingShingle | Qianqian Chen Xiangyi Xu Shun Li Tianqing Xiong LncRNA regulation in ischemic stroke and their application prospects Neural Regeneration Research adeno-associated virus angiogenesis autophagy gene therapy ischemic stroke long non-coding rnas neuroinflammation oxidative stress pathophysiological mechanism stroke |
| title | LncRNA regulation in ischemic stroke and their application prospects |
| title_full | LncRNA regulation in ischemic stroke and their application prospects |
| title_fullStr | LncRNA regulation in ischemic stroke and their application prospects |
| title_full_unstemmed | LncRNA regulation in ischemic stroke and their application prospects |
| title_short | LncRNA regulation in ischemic stroke and their application prospects |
| title_sort | lncrna regulation in ischemic stroke and their application prospects |
| topic | adeno-associated virus angiogenesis autophagy gene therapy ischemic stroke long non-coding rnas neuroinflammation oxidative stress pathophysiological mechanism stroke |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00924 |
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