The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review
Introduction: Vitamin D holds a crucial role in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Its mechanisms of action involve immune system modulation, specifically by reducing the production of pro-inflammatory cytokines, such a...
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56782 |
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| author | Wiktoria Maria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_facet | Wiktoria Maria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska |
| author_sort | Wiktoria Maria Tomaszewska |
| collection | DOAJ |
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Introduction: Vitamin D holds a crucial role in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Its mechanisms of action involve immune system modulation, specifically by reducing the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, while enhancing the levels of anti-inflammatory cytokines, such as IL-10. Furthermore, vitamin D contributes to the maintenance of intestinal barrier integrity by strengthening epithelial tight junctions. It also exerts a beneficial influence on the intestinal microbiota, promoting the proliferation of beneficial bacterial species, such as Faecalibacterium prausnitzii, which play a role in mitigating disease relapses and sustaining immune homeostasis. Although vitamin D supplementation demonstrates potential in reducing inflammation and improving clinical outcomes, the observed effects remain varied and require further investigation.
Aim: The purpose of this study was to analyze the mechanisms of action of vitamin D in the context of the pathogenesis of inflammatory bowel disease (IBD) and its potential therapeutic applications, with particular emphasis on clinical studies evaluating vitamin D supplementation.
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| format | Article |
| id | doaj-art-6285873a534a4a01b41e2346c2161197 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-6285873a534a4a01b41e2346c21611972025-01-20T08:17:09ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56782The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature reviewWiktoria Maria Tomaszewska0https://orcid.org/0009-0005-6166-1659Paweł Siudziński1https://orcid.org/0009-0002-4476-9412Mateusz Łyko2https://orcid.org/0009-0009-2530-2789Alicja Skoczylas3https://orcid.org/0009-0002-2185-5406Jakub Kurasz4https://orcid.org/0009-0004-3955-1552Wojciech Maj5https://orcid.org/0009-0003-2869-3718Wiktoria Podlasiewiczhttps://orcid.org/0009-0001-6578-5297Katarzyna Pala6https://orcid.org/0009-0004-0787-3872Piotr Dudziak7https://orcid.org/0009-0000-6173-740XAnna Nowak8https://orcid.org/0009-0005-8833-1107Maria Golińska9https://orcid.org/0009-0008-2772-6131Uniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet OpolskiUniwersytet Opolski Introduction: Vitamin D holds a crucial role in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Its mechanisms of action involve immune system modulation, specifically by reducing the production of pro-inflammatory cytokines, such as IL-6 and TNF-α, while enhancing the levels of anti-inflammatory cytokines, such as IL-10. Furthermore, vitamin D contributes to the maintenance of intestinal barrier integrity by strengthening epithelial tight junctions. It also exerts a beneficial influence on the intestinal microbiota, promoting the proliferation of beneficial bacterial species, such as Faecalibacterium prausnitzii, which play a role in mitigating disease relapses and sustaining immune homeostasis. Although vitamin D supplementation demonstrates potential in reducing inflammation and improving clinical outcomes, the observed effects remain varied and require further investigation. Aim: The purpose of this study was to analyze the mechanisms of action of vitamin D in the context of the pathogenesis of inflammatory bowel disease (IBD) and its potential therapeutic applications, with particular emphasis on clinical studies evaluating vitamin D supplementation. https://apcz.umk.pl/JEHS/article/view/56782Inflammatory bowel diseases (IBD)Crohn's disease (CD)ulcerative colitis (UC)vitamin Dsupplementationintestinal microbiome |
| spellingShingle | Wiktoria Maria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Jakub Kurasz Wojciech Maj Wiktoria Podlasiewicz Katarzyna Pala Piotr Dudziak Anna Nowak Maria Golińska The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review Journal of Education, Health and Sport Inflammatory bowel diseases (IBD) Crohn's disease (CD) ulcerative colitis (UC) vitamin D supplementation intestinal microbiome |
| title | The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review |
| title_full | The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review |
| title_fullStr | The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review |
| title_full_unstemmed | The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review |
| title_short | The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review |
| title_sort | role of vitamin d in the pathomechanism of inflammatory bowel disease ibd and its therapeutic implications a literature review |
| topic | Inflammatory bowel diseases (IBD) Crohn's disease (CD) ulcerative colitis (UC) vitamin D supplementation intestinal microbiome |
| url | https://apcz.umk.pl/JEHS/article/view/56782 |
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