Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents
Inflammatory bowel diseases (IBD) represent chronic inflammatory multisystemic disorders that primarily involve the gastrointestinal tract. Patients with ulcerative colitis (UC) and Crohn’s disease (CD) exhibit a higher prevalence of thyroid disorders compared to the general population. The aim of t...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1425241/full |
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| author | Valeria Calcaterra Valeria Calcaterra Francesca Penagini Virginia Rossi Luisa Abbattista Alice Bianchi Massimiliano Turzi Lucia Cococcioni Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_facet | Valeria Calcaterra Valeria Calcaterra Francesca Penagini Virginia Rossi Luisa Abbattista Alice Bianchi Massimiliano Turzi Lucia Cococcioni Gianvincenzo Zuccotti Gianvincenzo Zuccotti |
| author_sort | Valeria Calcaterra |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) represent chronic inflammatory multisystemic disorders that primarily involve the gastrointestinal tract. Patients with ulcerative colitis (UC) and Crohn’s disease (CD) exhibit a higher prevalence of thyroid disorders compared to the general population. The aim of this review is to summarize the literature on concomitant IBD and thyroid disorders, specifically autoimmune thyroid diseases such as Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), as well as thyroid cancer, with a focus on children and adolescents. We provide an overview of the age-related differences between children and adults in the prevalence of this association. Literature shows that relatively few studies have been conducted on this subject in pediatric populations. The etiopathogenetic similarities between IBD and autoimmune thyroiditis are undeniable. Nevertheless, current data does not indicate a unanimous association between GD and HT and chronic IBD (both CD and UC). Although evidence suggests a potential association between IBD and thyroid cancer, particularly papillary thyroid cancer, the precise nature of this relationship varies across studies and is influenced by multiple factors. The limited information regarding the relationship between IBD and thyroid disorders in children highlights a significant knowledge gap. Since the thyroid plays a critical role in the pediatric population’s development, it is essential to promptly recognize and treat thyroid diseases. A thyroid function monitoring and future research exploring the genetic and immunologic connections are essential to enhance our understanding of the interrelation between IBD and thyroid disorders. |
| format | Article |
| id | doaj-art-628497457dd44091b80084330d49b1ea |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-628497457dd44091b80084330d49b1ea2025-02-04T05:28:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14252411425241Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescentsValeria Calcaterra0Valeria Calcaterra1Francesca Penagini2Virginia Rossi3Luisa Abbattista4Alice Bianchi5Massimiliano Turzi6Lucia Cococcioni7Gianvincenzo Zuccotti8Gianvincenzo Zuccotti9Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyPediatric Department, Buzzi Children’s Hospital, Milano, ItalyDepartment of Biomedical and Clinical Science, University of Milan, Milano, ItalyInflammatory bowel diseases (IBD) represent chronic inflammatory multisystemic disorders that primarily involve the gastrointestinal tract. Patients with ulcerative colitis (UC) and Crohn’s disease (CD) exhibit a higher prevalence of thyroid disorders compared to the general population. The aim of this review is to summarize the literature on concomitant IBD and thyroid disorders, specifically autoimmune thyroid diseases such as Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), as well as thyroid cancer, with a focus on children and adolescents. We provide an overview of the age-related differences between children and adults in the prevalence of this association. Literature shows that relatively few studies have been conducted on this subject in pediatric populations. The etiopathogenetic similarities between IBD and autoimmune thyroiditis are undeniable. Nevertheless, current data does not indicate a unanimous association between GD and HT and chronic IBD (both CD and UC). Although evidence suggests a potential association between IBD and thyroid cancer, particularly papillary thyroid cancer, the precise nature of this relationship varies across studies and is influenced by multiple factors. The limited information regarding the relationship between IBD and thyroid disorders in children highlights a significant knowledge gap. Since the thyroid plays a critical role in the pediatric population’s development, it is essential to promptly recognize and treat thyroid diseases. A thyroid function monitoring and future research exploring the genetic and immunologic connections are essential to enhance our understanding of the interrelation between IBD and thyroid disorders.https://www.frontiersin.org/articles/10.3389/fendo.2025.1425241/fullthyroid disorderscancerchildrenadolescentsinflammatory bowel diseaseCrohn’s disease |
| spellingShingle | Valeria Calcaterra Valeria Calcaterra Francesca Penagini Virginia Rossi Luisa Abbattista Alice Bianchi Massimiliano Turzi Lucia Cococcioni Gianvincenzo Zuccotti Gianvincenzo Zuccotti Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents Frontiers in Endocrinology thyroid disorders cancer children adolescents inflammatory bowel disease Crohn’s disease |
| title | Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents |
| title_full | Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents |
| title_fullStr | Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents |
| title_full_unstemmed | Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents |
| title_short | Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents |
| title_sort | thyroid disorders and inflammatory bowel disease an association present in adults but also in children and adolescents |
| topic | thyroid disorders cancer children adolescents inflammatory bowel disease Crohn’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1425241/full |
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