Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital
Objective: to evaluate the early and long-term outcomes of cadaveric kidney allotransplantation (CKAT) based on a retrospective analysis of 71 cases treated at Krasnoyarsk Regional Clinical Hospital (KRCH).Materials and methods. From March 2014 to June 2019, 71 kidney transplants were performed at K...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-07-01
|
| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1292 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849399490538110976 |
|---|---|
| author | V. S. Arutyunyan A. V. Keosyan M. A. Firsov D. P. Evdokimov M. R. Tsokaev O. S. Amelchugova E. V. Lukicheva |
| author_facet | V. S. Arutyunyan A. V. Keosyan M. A. Firsov D. P. Evdokimov M. R. Tsokaev O. S. Amelchugova E. V. Lukicheva |
| author_sort | V. S. Arutyunyan |
| collection | DOAJ |
| description | Objective: to evaluate the early and long-term outcomes of cadaveric kidney allotransplantation (CKAT) based on a retrospective analysis of 71 cases treated at Krasnoyarsk Regional Clinical Hospital (KRCH).Materials and methods. From March 2014 to June 2019, 71 kidney transplants were performed at KRCH – 42 (59.15%) men and 29 (40.85%) women. The age of the patients varied from 20 to 59 years (mean age 39.6 ± 8.14 years). The causes of end-stage chronic kidney disease which subsequently led to CKAT were chronic glomerulonephritis, chronic tubulointerstitial nephritis, hypertensive nephropathy (HN), diabetic nephropathy resulting from type I diabetes (DN), nephropathy of mixed genesis (HN + DN), vesicoureteral reflux, congenital angiodysplasia of the kidneys, and Alport syndrome. The mean number of HLA mismatches was 4.5 ± 0.9.Results. Hospitalization lasted for an average of 34.05 ± 9.56 days. Primary function was observed in 32 (45.08%) patients, while 39 (54.92%) cases had delayed function. Post-transplant complications were noted in 23 (32.39%) patients, of whom 12 (16.9%) had early post-transplant complications, while 15 (21.13%) encountered complications in the late post-transplant period. The most frequently diagnosed were immunological, infectious, and urological complications. Vascular, surgical, oncological, and other complications were less frequent. The annual graft survival rate was 87.3%. Patient survival rate was 95.77%. One (1.4%) and 2 (2.81%) patients died in the early and late post-transplant periods, respectively. Hospital mortality – 1 case (1.4%).Conclusion. Kidney transplantation is the most effective treatment for patients with irreversible chronic kidney disease. About 87.33% of transplants were found to be effective. However, 32.39% of patients had postoperative complications. The vast majority of complications were reversible and were corrected conservatively or surgically. Nevertheless, graft loss occurred in 12.67% of cases. The success of transplantation depends on a number of factors related to both the donor and the recipient, as well as the immunological status and surgical technique. A personalized approach to recipients helps to reduce postoperative complications, prevent nephrotoxicity and rejection reactions. |
| format | Article |
| id | doaj-art-62831ae6776f447e9be7cb56cdaf921c |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2021-07-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-62831ae6776f447e9be7cb56cdaf921c2025-08-20T03:38:19ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912021-07-01232415110.15825/1995-1191-2021-2-41-51980Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical HospitalV. S. Arutyunyan0A. V. Keosyan1M. A. Firsov2D. P. Evdokimov3M. R. Tsokaev4O. S. Amelchugova5E. V. Lukicheva6Krasnoyarsk State Medical UniversityKrasnoyarsk State Medical UniversityKrasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalKrasnoyarsk Regional Clinical HospitalKrasnoyarsk Regional Clinical HospitalKrasnoyarsk Regional Clinical HospitalKrasnoyarsk Regional Clinical HospitalObjective: to evaluate the early and long-term outcomes of cadaveric kidney allotransplantation (CKAT) based on a retrospective analysis of 71 cases treated at Krasnoyarsk Regional Clinical Hospital (KRCH).Materials and methods. From March 2014 to June 2019, 71 kidney transplants were performed at KRCH – 42 (59.15%) men and 29 (40.85%) women. The age of the patients varied from 20 to 59 years (mean age 39.6 ± 8.14 years). The causes of end-stage chronic kidney disease which subsequently led to CKAT were chronic glomerulonephritis, chronic tubulointerstitial nephritis, hypertensive nephropathy (HN), diabetic nephropathy resulting from type I diabetes (DN), nephropathy of mixed genesis (HN + DN), vesicoureteral reflux, congenital angiodysplasia of the kidneys, and Alport syndrome. The mean number of HLA mismatches was 4.5 ± 0.9.Results. Hospitalization lasted for an average of 34.05 ± 9.56 days. Primary function was observed in 32 (45.08%) patients, while 39 (54.92%) cases had delayed function. Post-transplant complications were noted in 23 (32.39%) patients, of whom 12 (16.9%) had early post-transplant complications, while 15 (21.13%) encountered complications in the late post-transplant period. The most frequently diagnosed were immunological, infectious, and urological complications. Vascular, surgical, oncological, and other complications were less frequent. The annual graft survival rate was 87.3%. Patient survival rate was 95.77%. One (1.4%) and 2 (2.81%) patients died in the early and late post-transplant periods, respectively. Hospital mortality – 1 case (1.4%).Conclusion. Kidney transplantation is the most effective treatment for patients with irreversible chronic kidney disease. About 87.33% of transplants were found to be effective. However, 32.39% of patients had postoperative complications. The vast majority of complications were reversible and were corrected conservatively or surgically. Nevertheless, graft loss occurred in 12.67% of cases. The success of transplantation depends on a number of factors related to both the donor and the recipient, as well as the immunological status and surgical technique. A personalized approach to recipients helps to reduce postoperative complications, prevent nephrotoxicity and rejection reactions.https://journal.transpl.ru/vtio/article/view/1292kidney transplantationchronic kidney disease |
| spellingShingle | V. S. Arutyunyan A. V. Keosyan M. A. Firsov D. P. Evdokimov M. R. Tsokaev O. S. Amelchugova E. V. Lukicheva Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital Вестник трансплантологии и искусственных органов kidney transplantation chronic kidney disease |
| title | Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital |
| title_full | Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital |
| title_fullStr | Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital |
| title_full_unstemmed | Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital |
| title_short | Cadaveric kidney allotransplantation at Krasnoyarsk Regional Clinical Hospital |
| title_sort | cadaveric kidney allotransplantation at krasnoyarsk regional clinical hospital |
| topic | kidney transplantation chronic kidney disease |
| url | https://journal.transpl.ru/vtio/article/view/1292 |
| work_keys_str_mv | AT vsarutyunyan cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT avkeosyan cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT mafirsov cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT dpevdokimov cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT mrtsokaev cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT osamelchugova cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital AT evlukicheva cadaverickidneyallotransplantationatkrasnoyarskregionalclinicalhospital |