Sex and Gender Differences in Fibromuscular Dysplasia
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease that was once underrecognized and is significantly more prevalent in women than men. Although it most commonly affects the renal and extracranial carotid arteries, FMD can affect any vascular bed. Complications...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2024-07-01
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| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articleindex/usc.2023.03 |
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| _version_ | 1850104554319773696 |
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| author | Marianne H Khoury Sims Hershey Rebecca M LeLeiko |
| author_facet | Marianne H Khoury Sims Hershey Rebecca M LeLeiko |
| author_sort | Marianne H Khoury |
| collection | DOAJ |
| description | Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease that was once underrecognized and is significantly more prevalent in women than men. Although it most commonly affects the renal and extracranial carotid arteries, FMD can affect any vascular bed. Complications of FMD can include hypertension, dissection, and stroke. Presentation may vary between the sexes, with male patients having an increased frequency of arterial dissection and aneurysms compared with female patients. Diagnosis requires a high index of suspicion by the treating physician. Several imaging studies can assist with diagnosis, and treatment focuses on the monitoring of affected vessels and intervention only as needed. Antiplatelet therapy for prevention of thrombotic complications is recommended. Studies are still underway to examine the genetic underpinnings of FMD pathophysiology and to evaluate the underlying mechanism of this disease that affects more female than male patients. |
| format | Article |
| id | doaj-art-627a5da465f340ec8cce3f7f2117cf67 |
| institution | DOAJ |
| issn | 1758-3896 1758-390X |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj-art-627a5da465f340ec8cce3f7f2117cf672025-08-20T02:39:18ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2024-07-011810.15420/usc.2023.03Sex and Gender Differences in Fibromuscular DysplasiaMarianne H Khoury0Sims Hershey1Rebecca M LeLeiko2Department of Medicine, Emory University School of Medicine, Atlanta, GADepartment of Medicine, Vanderbilt University Medical Center, Nashville, TNDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GAFibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease that was once underrecognized and is significantly more prevalent in women than men. Although it most commonly affects the renal and extracranial carotid arteries, FMD can affect any vascular bed. Complications of FMD can include hypertension, dissection, and stroke. Presentation may vary between the sexes, with male patients having an increased frequency of arterial dissection and aneurysms compared with female patients. Diagnosis requires a high index of suspicion by the treating physician. Several imaging studies can assist with diagnosis, and treatment focuses on the monitoring of affected vessels and intervention only as needed. Antiplatelet therapy for prevention of thrombotic complications is recommended. Studies are still underway to examine the genetic underpinnings of FMD pathophysiology and to evaluate the underlying mechanism of this disease that affects more female than male patients.https://www.uscjournal.com/articleindex/usc.2023.03 |
| spellingShingle | Marianne H Khoury Sims Hershey Rebecca M LeLeiko Sex and Gender Differences in Fibromuscular Dysplasia US Cardiology Review |
| title | Sex and Gender Differences in Fibromuscular Dysplasia |
| title_full | Sex and Gender Differences in Fibromuscular Dysplasia |
| title_fullStr | Sex and Gender Differences in Fibromuscular Dysplasia |
| title_full_unstemmed | Sex and Gender Differences in Fibromuscular Dysplasia |
| title_short | Sex and Gender Differences in Fibromuscular Dysplasia |
| title_sort | sex and gender differences in fibromuscular dysplasia |
| url | https://www.uscjournal.com/articleindex/usc.2023.03 |
| work_keys_str_mv | AT mariannehkhoury sexandgenderdifferencesinfibromusculardysplasia AT simshershey sexandgenderdifferencesinfibromusculardysplasia AT rebeccamleleiko sexandgenderdifferencesinfibromusculardysplasia |