Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies

Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies

Abstract Hantaan orthohantavirus (HTNV) is responsible for severe hemorrhagic fever with renal syndrome (HFRS), which has a case fatality rate of 1% to 10%. Currently, the inactive vaccine licensed in endemic areas elicit low levels of neutralizing antibodies (NAbs). Early NAbs administration is hel...

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Main Authors: Jing Wei, Hui Zhang, Jiawei Pei, Qiqi Yang, Yuan Wang, Xiaolei Jin, He Liu, Liang Zhang, Hongwei Ma, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Yinlan Bai, Zhikai Xu, Pengbo Yu, Fanglin Zhang, Wei Ye
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Virology Journal
Subjects:
Hantaan orthohantavirus (HTNV)
Hemorrhagic fever with renal syndrome (HFRS)
Vesicular stomatitis virus (VSV)
Neutralizing antibodies (NAbs)
Focus reduction neutralization test (FRNT)
Plaque reduction neutralization test (PRNT)
Online Access:https://doi.org/10.1186/s12985-024-02613-6
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