MicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth

MicroRNA profiling identifies VHL/HIF-2α dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth

Abstract Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is one of the first truncal events in clear cell Renal Cell Carcinoma (ccRCC) tumorigenesis. The accumulation of Hypoxia Induced Factor (HIFα) resulting from VHL loss can promote ccRCC tumorigenesis by regulating microRNA (mi...

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Bibliographic Details
Main Authors: Patric M. Page, Sonia A. Dastous, Patrick O. Richard, Michel Pavic, Tamiko Nishimura, Yasser Riazalhosseini, Nicolas Crapoulet, Mykella Martin, Sandra Turcotte
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Subjects:
ccRCC
VHL
HIF
miRNAs
miR-2355-5p
Tumor growth
Online Access:https://doi.org/10.1186/s12935-025-03711-3
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