ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells.

ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells.

The Hippo pathway, by tightly controlling the phosphorylation state and activity of the transcription cofactors YAP and TAZ is essential during development and tissue homeostasis whereas its deregulation may lead to cancer. Recent studies have linked the apicobasal polarity machinery in epithelial c...

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Bibliographic Details
Main Authors: Christophe Royer, Sofia Koch, Xiao Qin, Jaroslav Zak, Ludovico Buti, Ewa Dudziec, Shan Zhong, Indrika Ratnayaka, Shankar Srinivas, Xin Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0111384
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