Isoform switch of T-cell factor7L2 during mouse heart development

Isoform switch of T-cell factor7L2 during mouse heart development

Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, contributes to WNT signaling specificity in the heart. To inves...

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Bibliographic Details
Main Authors: Bo Ye, Lu Xiao, Yuyong Xu, Haodong Xu, Faqian Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Tcf7l2
Heart development
Isoform
Alternative splicing
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125001771
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