Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases
As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the research of these illnesses, little progress has been made in the creation of novel diagnostic and ther...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1496304/full |
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| author | Haibin Shen Jie Chen Meijin Liu Minghong Zhao Die Hu Fangfang Xie Qing Jin Dewang Xiao Zongbo Peng Tao Qin Dingyu Rao Defa Huang |
| author_facet | Haibin Shen Jie Chen Meijin Liu Minghong Zhao Die Hu Fangfang Xie Qing Jin Dewang Xiao Zongbo Peng Tao Qin Dingyu Rao Defa Huang |
| author_sort | Haibin Shen |
| collection | DOAJ |
| description | As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the research of these illnesses, little progress has been made in the creation of novel diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are released by all cell types and contain proteins, microRNAs, mRNAs, and other biologically active molecules. EVs play an important role in intercellular communication as well as in the regulation of neuroinflammation. Determining the mechanisms by which EVs contribute to the pathogenesis of neurodegenerative diseases will aid in the development of new therapeutic approaches and diagnostic tools. Mesenchymal stem cells (MSCs) have been shown in studies to control immunological responses, promote the growth of new brain connections, promote the production of blood vessels, and heal damaged tissues. There is growing evidence that MSCs’ ability to treat patients is mostly due to the neurotrophic compounds they secrete through EVs. Since their tiny size allows them to pass through biological barriers and reach injured parts of the central nervous system, MSC-derived extracellular vesicles (MSC-EVs) retain many of the therapeutic qualities of their parent MSCs. This review discusses the role of EVs in neurodegenerative diseases and highlights the potential of MSC-EVs in the treatment of neurodegenerative diseases. The paper also examines the challenges that still need to be overcome and the prospects for using MSC-EVs to treat neurodegenerative illnesses. |
| format | Article |
| id | doaj-art-62609ada7cdb4fbb9282e714fbc4517a |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-62609ada7cdb4fbb9282e714fbc4517a2025-08-20T02:54:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.14963041496304Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseasesHaibin Shen0Jie Chen1Meijin Liu2Minghong Zhao3Die Hu4Fangfang Xie5Qing Jin6Dewang Xiao7Zongbo Peng8Tao Qin9Dingyu Rao10Defa Huang11Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Laboratory Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, Yongchuan, ChinaLaboratory Medicine, People’s Hospital of Ganzhou Economic Development Zone, Ganzhou, ChinaLaboratory Medicine, Guizhou Aerospace Hospital, Zunyi, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, Guizhou Aerospace Hospital, Zunyi, ChinaDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaAs the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the research of these illnesses, little progress has been made in the creation of novel diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are released by all cell types and contain proteins, microRNAs, mRNAs, and other biologically active molecules. EVs play an important role in intercellular communication as well as in the regulation of neuroinflammation. Determining the mechanisms by which EVs contribute to the pathogenesis of neurodegenerative diseases will aid in the development of new therapeutic approaches and diagnostic tools. Mesenchymal stem cells (MSCs) have been shown in studies to control immunological responses, promote the growth of new brain connections, promote the production of blood vessels, and heal damaged tissues. There is growing evidence that MSCs’ ability to treat patients is mostly due to the neurotrophic compounds they secrete through EVs. Since their tiny size allows them to pass through biological barriers and reach injured parts of the central nervous system, MSC-derived extracellular vesicles (MSC-EVs) retain many of the therapeutic qualities of their parent MSCs. This review discusses the role of EVs in neurodegenerative diseases and highlights the potential of MSC-EVs in the treatment of neurodegenerative diseases. The paper also examines the challenges that still need to be overcome and the prospects for using MSC-EVs to treat neurodegenerative illnesses.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1496304/fullmesenchymal stem cellsextracellular vesiclesneurodegenerative diseasetreatmentdiagnosis |
| spellingShingle | Haibin Shen Jie Chen Meijin Liu Minghong Zhao Die Hu Fangfang Xie Qing Jin Dewang Xiao Zongbo Peng Tao Qin Dingyu Rao Defa Huang Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases Frontiers in Immunology mesenchymal stem cells extracellular vesicles neurodegenerative disease treatment diagnosis |
| title | Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| title_full | Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| title_fullStr | Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| title_full_unstemmed | Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| title_short | Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| title_sort | research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases |
| topic | mesenchymal stem cells extracellular vesicles neurodegenerative disease treatment diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1496304/full |
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