Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis
The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisom...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2012/659016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849411760471146496 |
|---|---|
| author | Elenice Ferreira Bastos Lidiane Alice Silva Marcelo Coelho Ramos Glicínia Pimenta Paulo Ivo Cortez Stella Beatriz Gonçalves de Lucena Teresa de Souza Fernandez |
| author_facet | Elenice Ferreira Bastos Lidiane Alice Silva Marcelo Coelho Ramos Glicínia Pimenta Paulo Ivo Cortez Stella Beatriz Gonçalves de Lucena Teresa de Souza Fernandez |
| author_sort | Elenice Ferreira Bastos |
| collection | DOAJ |
| description | The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL. |
| format | Article |
| id | doaj-art-62604552701a4e8c8bfcc5f6e6addbaa |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-62604552701a4e8c8bfcc5f6e6addbaa2025-08-20T03:34:41ZengWileyCase Reports in Genetics2090-65442090-65522012-01-01201210.1155/2012/659016659016Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor PrognosisElenice Ferreira Bastos0Lidiane Alice Silva1Marcelo Coelho Ramos2Glicínia Pimenta3Paulo Ivo Cortez4Stella Beatriz Gonçalves de Lucena5Teresa de Souza Fernandez6Faculty of Medical Sciences, State University of Rio de Janeiro, 20551-120 Rio de Janeiro, RJ, BrazilFaculty of Medical Sciences, State University of Rio de Janeiro, 20551-120 Rio de Janeiro, RJ, BrazilFaculty of Medical Sciences, State University of Rio de Janeiro, 20551-120 Rio de Janeiro, RJ, BrazilHematology Service, HUCFF, UFRJ, 20551-120 Rio de Janeiro, RJ, BrazilPronto Baby Children’s Hospital, 20551-120 Rio de Janeiro, RJ, BrazilFaculty of Medical Sciences, State University of Rio de Janeiro, 20551-120 Rio de Janeiro, RJ, BrazilBone Marrow Transplant Center, National Cancer Institute (INCA), 20551-120 Rio de Janeiro, RJ, BrazilThe prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL.http://dx.doi.org/10.1155/2012/659016 |
| spellingShingle | Elenice Ferreira Bastos Lidiane Alice Silva Marcelo Coelho Ramos Glicínia Pimenta Paulo Ivo Cortez Stella Beatriz Gonçalves de Lucena Teresa de Souza Fernandez Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis Case Reports in Genetics |
| title | Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis |
| title_full | Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis |
| title_fullStr | Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis |
| title_full_unstemmed | Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis |
| title_short | Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis |
| title_sort | trisomy 11 as an additional chromosome alteration in a child with acute promyelocytic leukemia with poor prognosis |
| url | http://dx.doi.org/10.1155/2012/659016 |
| work_keys_str_mv | AT eleniceferreirabastos trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT lidianealicesilva trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT marcelocoelhoramos trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT gliciniapimenta trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT pauloivocortez trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT stellabeatrizgoncalvesdelucena trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis AT teresadesouzafernandez trisomy11asanadditionalchromosomealterationinachildwithacutepromyelocyticleukemiawithpoorprognosis |