A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control
BackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention in...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1515598/full |
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| author | Philip Düsing Stephan H. Schirmer Sebastian Schäfer Alexander Krogmann Jan-Malte Sinning Nikos Werner Florian Bönner Alexander Sedaghat Cornelius Müller Irina Eckardt Georg Nickenig Andreas Zietzer |
| author_facet | Philip Düsing Stephan H. Schirmer Sebastian Schäfer Alexander Krogmann Jan-Malte Sinning Nikos Werner Florian Bönner Alexander Sedaghat Cornelius Müller Irina Eckardt Georg Nickenig Andreas Zietzer |
| author_sort | Philip Düsing |
| collection | DOAJ |
| description | BackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy. The CHANGE study aimed to provide evidence for optimizing secondary prevention in CCS patients using a smartphone application.MethodsThe CHANGE-Study is a prospective, randomized, controlled trial performed in 9 centers in Germany. Patients with CCS were randomly allocated to either a control or an intervention group. The intervention group received the “Vantis | KHK und Herzinfarkt” digital health application and standard care. The control group received standard care alone. From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). This observation was consistent in patients with systolic BP ≥130 mmHg at baseline. No significant differences between both groups were observed in diastolic BP reduction in patients with diastolic BP ≥90 mmHg.ConclusionThe CHANGE study documents that a smartphone-guided digital health application positively affects systolic BP in CCS patients. This study underlines the potential of digital interventions in cardiology to improve secondary prevention. |
| format | Article |
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| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-625d71508bc142e7ad5364340dd8e3f82025-02-10T06:48:43ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15155981515598A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure controlPhilip Düsing0Stephan H. Schirmer1Sebastian Schäfer2Alexander Krogmann3Jan-Malte Sinning4Nikos Werner5Florian Bönner6Alexander Sedaghat7Cornelius Müller8Irina Eckardt9Georg Nickenig10Andreas Zietzer11Department of Medicine II, Heart Center, University Hospital Bonn, Bonn, GermanyKardiopraxis Schirmer, Kaiserslautern, GermanyPraxis Rheingalerie Rodenkirchen, Cologne, GermanyKardio-Lev, Kardiologische Gemeinschaftspraxis Dr. P. Son, Dr. M. Päsler, Dr. A. Krogmann, Leverkusen, GermanyDepartment of Cardiology, St. Vinzenz Hospital, Cologne, GermanyMedical Department III, Heart Center Trier, Krankenhaus der Barmherzigen Brüder, Trier, GermanyDepartment of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of Heinrich Heine University, University Hospital Düsseldorf, Düsseldorf, GermanyRhein-Ahr-Cardio, Praxis für Kardiologie, Bad Neuenahr-Ahrweiler, GermanyKardio Bonn, Gemeinschaftspraxis Dr. La Rosée & Prof. Müller, Bonn, GermanyDepartment of Medicine II, Heart Center, University Hospital Bonn, Bonn, GermanyDepartment of Medicine II, Heart Center, University Hospital Bonn, Bonn, GermanyDepartment of Medicine II, Heart Center, University Hospital Bonn, Bonn, GermanyBackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy. The CHANGE study aimed to provide evidence for optimizing secondary prevention in CCS patients using a smartphone application.MethodsThe CHANGE-Study is a prospective, randomized, controlled trial performed in 9 centers in Germany. Patients with CCS were randomly allocated to either a control or an intervention group. The intervention group received the “Vantis | KHK und Herzinfarkt” digital health application and standard care. The control group received standard care alone. From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). This observation was consistent in patients with systolic BP ≥130 mmHg at baseline. No significant differences between both groups were observed in diastolic BP reduction in patients with diastolic BP ≥90 mmHg.ConclusionThe CHANGE study documents that a smartphone-guided digital health application positively affects systolic BP in CCS patients. This study underlines the potential of digital interventions in cardiology to improve secondary prevention.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1515598/fullchronic coronary syndromesecondary preventiondigital healthhypertensionsmartphone |
| spellingShingle | Philip Düsing Stephan H. Schirmer Sebastian Schäfer Alexander Krogmann Jan-Malte Sinning Nikos Werner Florian Bönner Alexander Sedaghat Cornelius Müller Irina Eckardt Georg Nickenig Andreas Zietzer A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control Frontiers in Cardiovascular Medicine chronic coronary syndrome secondary prevention digital health hypertension smartphone |
| title | A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| title_full | A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| title_fullStr | A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| title_full_unstemmed | A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| title_short | A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| title_sort | smartphone guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control |
| topic | chronic coronary syndrome secondary prevention digital health hypertension smartphone |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1515598/full |
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