T Helper 17 Cells in Autoimmune Liver Diseases
Many autoimmune diseases are driven by self-reactive T helper (Th) cells. A new population of effector CD4+ T cells characterized by the secretion of interleukin (IL)-17, referred to as Th17 cells, has been demonstrated to be phenotypically, functionally, and developmentally distinct from Th1 and Th...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/607073 |
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| author | Masanori Abe Yoichi Hiasa Morikazu Onji |
| author_facet | Masanori Abe Yoichi Hiasa Morikazu Onji |
| author_sort | Masanori Abe |
| collection | DOAJ |
| description | Many autoimmune diseases are driven by self-reactive T helper (Th) cells. A new population of effector CD4+ T cells characterized by the secretion of interleukin (IL)-17, referred to as Th17 cells, has been demonstrated to be phenotypically, functionally, and developmentally distinct from Th1 and Th2 cells. Because the liver is known to be an important source of transforming growth factor-β and IL-6, which are cytokines that are crucial for Th17 differentiation, it is very likely that Th17 cells contribute to liver inflammation and autoimmunity. In contrast, another distinct subset of T cells, regulatory T cells (Treg), downregulate immune responses and play an important role in maintaining self-tolerance. In addition, there is a reciprocal relationship between Th17 cells and Tregs, in development and effector functions, and the balance between Th17 and Treg cells can affect the outcome of immune responses, particularly in autoimmune diseases. In this review, we will focus on the latest investigative findings related to Th17 cells in autoimmune liver disease. |
| format | Article |
| id | doaj-art-62531f52330e4154b350ae2c7fecb014 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-62531f52330e4154b350ae2c7fecb0142025-02-03T05:47:30ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/607073607073T Helper 17 Cells in Autoimmune Liver DiseasesMasanori Abe0Yoichi Hiasa1Morikazu Onji2Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, To-on, Ehime 791-0295, JapanDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, To-on, Ehime 791-0295, JapanDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, To-on, Ehime 791-0295, JapanMany autoimmune diseases are driven by self-reactive T helper (Th) cells. A new population of effector CD4+ T cells characterized by the secretion of interleukin (IL)-17, referred to as Th17 cells, has been demonstrated to be phenotypically, functionally, and developmentally distinct from Th1 and Th2 cells. Because the liver is known to be an important source of transforming growth factor-β and IL-6, which are cytokines that are crucial for Th17 differentiation, it is very likely that Th17 cells contribute to liver inflammation and autoimmunity. In contrast, another distinct subset of T cells, regulatory T cells (Treg), downregulate immune responses and play an important role in maintaining self-tolerance. In addition, there is a reciprocal relationship between Th17 cells and Tregs, in development and effector functions, and the balance between Th17 and Treg cells can affect the outcome of immune responses, particularly in autoimmune diseases. In this review, we will focus on the latest investigative findings related to Th17 cells in autoimmune liver disease.http://dx.doi.org/10.1155/2013/607073 |
| spellingShingle | Masanori Abe Yoichi Hiasa Morikazu Onji T Helper 17 Cells in Autoimmune Liver Diseases Clinical and Developmental Immunology |
| title | T Helper 17 Cells in Autoimmune Liver Diseases |
| title_full | T Helper 17 Cells in Autoimmune Liver Diseases |
| title_fullStr | T Helper 17 Cells in Autoimmune Liver Diseases |
| title_full_unstemmed | T Helper 17 Cells in Autoimmune Liver Diseases |
| title_short | T Helper 17 Cells in Autoimmune Liver Diseases |
| title_sort | t helper 17 cells in autoimmune liver diseases |
| url | http://dx.doi.org/10.1155/2013/607073 |
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