Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
Abstract The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology and the innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected with tumorigenes...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-024-02219-0 |
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| _version_ | 1832594974003167232 |
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| author | Qibo Huang Bai Hu Ping Zhang Ye Yuan Shiwei Yue Xiaoping Chen Junnan Liang Zhouping Tang Bixiang Zhang |
| author_facet | Qibo Huang Bai Hu Ping Zhang Ye Yuan Shiwei Yue Xiaoping Chen Junnan Liang Zhouping Tang Bixiang Zhang |
| author_sort | Qibo Huang |
| collection | DOAJ |
| description | Abstract The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology and the innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected with tumorigenesis. In particular, the peripheral and central nervous systems, synapse, neurotransmitters, and neurotrophins affect tumor progression and metastasis through various regulatory approaches and the tumor immune microenvironment. In this review, we summarized the neurological functions that affect tumorigenesis and metastasis, which are controlled by the central and peripheral nervous systems. We also explored the roles of neurotransmitters and neurotrophins in cancer progression. Moreover, we examined the interplay between the nervous system and the tumor immune microenvironment. We have also identified drugs that target the nervous system for cancer treatment. In this review we present the work supporting that therapeutic agent targeting the nervous system could have significant potential to improve cancer therapy. |
| format | Article |
| id | doaj-art-624b12d0e7b245ddb3504ccb64834487 |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-624b12d0e7b245ddb3504ccb648344872025-01-19T12:12:39ZengBMCMolecular Cancer1476-45982025-01-0124113010.1186/s12943-024-02219-0Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironmentQibo Huang0Bai Hu1Ping Zhang2Ye Yuan3Shiwei Yue4Xiaoping Chen5Junnan Liang6Zhouping Tang7Bixiang Zhang8Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & InstituteHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology and the innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected with tumorigenesis. In particular, the peripheral and central nervous systems, synapse, neurotransmitters, and neurotrophins affect tumor progression and metastasis through various regulatory approaches and the tumor immune microenvironment. In this review, we summarized the neurological functions that affect tumorigenesis and metastasis, which are controlled by the central and peripheral nervous systems. We also explored the roles of neurotransmitters and neurotrophins in cancer progression. Moreover, we examined the interplay between the nervous system and the tumor immune microenvironment. We have also identified drugs that target the nervous system for cancer treatment. In this review we present the work supporting that therapeutic agent targeting the nervous system could have significant potential to improve cancer therapy.https://doi.org/10.1186/s12943-024-02219-0NeuroscienceNervous systemNeurotransmittersTumorigenesisTumor immune microenvironmentNeuromodulatory drugs |
| spellingShingle | Qibo Huang Bai Hu Ping Zhang Ye Yuan Shiwei Yue Xiaoping Chen Junnan Liang Zhouping Tang Bixiang Zhang Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment Molecular Cancer Neuroscience Nervous system Neurotransmitters Tumorigenesis Tumor immune microenvironment Neuromodulatory drugs |
| title | Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment |
| title_full | Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment |
| title_fullStr | Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment |
| title_full_unstemmed | Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment |
| title_short | Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment |
| title_sort | neuroscience of cancer unraveling the complex interplay between the nervous system the tumor and the tumor immune microenvironment |
| topic | Neuroscience Nervous system Neurotransmitters Tumorigenesis Tumor immune microenvironment Neuromodulatory drugs |
| url | https://doi.org/10.1186/s12943-024-02219-0 |
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