A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity
Trastuzumab is a monoclonal antibody highly effective in the treatment of several cancers, but its use is associated with cardiac toxicity which usually responds to cessation of the drug and/or medical therapy. We present an unusual case of acute cardiac toxicity temporally related to administration...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2013/473979 |
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| author | Sylvana Hidalgo Carol A. Albright Gretchen L. Wells |
| author_facet | Sylvana Hidalgo Carol A. Albright Gretchen L. Wells |
| author_sort | Sylvana Hidalgo |
| collection | DOAJ |
| description | Trastuzumab is a monoclonal antibody highly effective in the treatment of several cancers, but its use is associated with cardiac toxicity which usually responds to cessation of the drug and/or medical therapy. We present an unusual case of acute cardiac toxicity temporally related to administration of trastuzumab in which the clinical presentation suggested an acute coronary syndrome. Coronary angiography, however, demonstrated minimal epicardial disease, but new wall motion abnormalities. Furthermore, the patient did not respond to withdrawal of the drug or medical therapy for heart failure. |
| format | Article |
| id | doaj-art-62436d00671e469da1698ebf0c7cab05 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-62436d00671e469da1698ebf0c7cab052025-02-03T01:02:48ZengWileyCase Reports in Cardiology2090-64042090-64122013-01-01201310.1155/2013/473979473979A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab CardiotoxicitySylvana Hidalgo0Carol A. Albright1Gretchen L. Wells2Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USADepartment of Internal Medicine, Section on Hematology and Oncology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USADepartment of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USATrastuzumab is a monoclonal antibody highly effective in the treatment of several cancers, but its use is associated with cardiac toxicity which usually responds to cessation of the drug and/or medical therapy. We present an unusual case of acute cardiac toxicity temporally related to administration of trastuzumab in which the clinical presentation suggested an acute coronary syndrome. Coronary angiography, however, demonstrated minimal epicardial disease, but new wall motion abnormalities. Furthermore, the patient did not respond to withdrawal of the drug or medical therapy for heart failure.http://dx.doi.org/10.1155/2013/473979 |
| spellingShingle | Sylvana Hidalgo Carol A. Albright Gretchen L. Wells A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity Case Reports in Cardiology |
| title | A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity |
| title_full | A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity |
| title_fullStr | A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity |
| title_full_unstemmed | A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity |
| title_short | A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity |
| title_sort | case of trastuzumab associated cardiomyopathy presenting as an acute coronary syndrome acute trastuzumab cardiotoxicity |
| url | http://dx.doi.org/10.1155/2013/473979 |
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