Physicochemical characterization of micafungin and anidulafungin for its nebulized administration
Objective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization. Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry i...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Farmacia Hospitalaria |
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| Online Access: | http://www.aulamedica.es/fh/pdf/11226.pdf |
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| author | Sonia Terradas-Campanario Laura Gómez-Ganda David Campany-Herrero |
| author_facet | Sonia Terradas-Campanario Laura Gómez-Ganda David Campany-Herrero |
| author_sort | Sonia Terradas-Campanario |
| collection | DOAJ |
| description | Objective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization.
Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin.
Results: The results obtained for micafungin solution were: pH 5.80 (0.14), osmolality 293.33 (1.53) mOsm/kg, chloride content 134.67 (0.58) mmol/L and density 1,009.4 (0,1) kg/m3; while for 10 mg/mL solution: osmolality 342.00 (1.00) mOsm/kg, chloride content 139.67 (0.58) mmol/L and density 1,014.5 (0.2) kg/m3. The results obtained for 5 mg/mL anidulafungin were: pH 4.22 (0.01), osmolality 464.67 (2.52) mOsm/kg, chloride content 137.00 (0.00) mmol/L and density 1,016.5 (0,2) kg/m3; while for 10 mg/mL solution: osmolality 656.33 (1.15) mOsm/kg, chloride content 132.00 (0.00) mmol/L and density 1,029.8 (0.4) kg/m3.
Conclusions: PH, osmolality, chloride content and density values proved to be suitable for proper tolerability by nebulization. |
| format | Article |
| id | doaj-art-623ee539764141cfb143099b056cba2b |
| institution | Kabale University |
| issn | 1130-6343 2171-8695 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Farmacia Hospitalaria |
| spelling | doaj-art-623ee539764141cfb143099b056cba2b2024-12-02T06:55:51ZengElsevierFarmacia Hospitalaria1130-63432171-86952019-09-0143516316510.7399/fh.11226Physicochemical characterization of micafungin and anidulafungin for its nebulized administrationSonia Terradas-Campanario0Laura Gómez-Ganda1David Campany-Herrero2Pharmacy Service. Vall d’Hebron University Hospital. Barcelona. SpainPharmacy Service. Vall d’Hebron University Hospital. Barcelona. SpainPharmacy Service. Vall d’Hebron University Hospital. Barcelona. SpainObjective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization. Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin. Results: The results obtained for micafungin solution were: pH 5.80 (0.14), osmolality 293.33 (1.53) mOsm/kg, chloride content 134.67 (0.58) mmol/L and density 1,009.4 (0,1) kg/m3; while for 10 mg/mL solution: osmolality 342.00 (1.00) mOsm/kg, chloride content 139.67 (0.58) mmol/L and density 1,014.5 (0.2) kg/m3. The results obtained for 5 mg/mL anidulafungin were: pH 4.22 (0.01), osmolality 464.67 (2.52) mOsm/kg, chloride content 137.00 (0.00) mmol/L and density 1,016.5 (0,2) kg/m3; while for 10 mg/mL solution: osmolality 656.33 (1.15) mOsm/kg, chloride content 132.00 (0.00) mmol/L and density 1,029.8 (0.4) kg/m3. Conclusions: PH, osmolality, chloride content and density values proved to be suitable for proper tolerability by nebulization.http://www.aulamedica.es/fh/pdf/11226.pdfMicafunginAnidulafunginAntifungalNebulizedScedosporiumScopulariopsis |
| spellingShingle | Sonia Terradas-Campanario Laura Gómez-Ganda David Campany-Herrero Physicochemical characterization of micafungin and anidulafungin for its nebulized administration Farmacia Hospitalaria Micafungin Anidulafungin Antifungal Nebulized Scedosporium Scopulariopsis |
| title | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| title_full | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| title_fullStr | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| title_full_unstemmed | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| title_short | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| title_sort | physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| topic | Micafungin Anidulafungin Antifungal Nebulized Scedosporium Scopulariopsis |
| url | http://www.aulamedica.es/fh/pdf/11226.pdf |
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