Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing

Summary: Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that diversifies the transcriptome and influences various cellular processes, yet its regulatory mechanisms remain largely unknown. Here, we present two complementary CRISPR-based genetic screening pla...

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Bibliographic Details
Main Authors: Tianzi Wei, Jiaxuan Li, Xiang Lei, Risheng Lin, Qingyan Wu, Zhenfeng Zhang, Shimin Shuai, Ruilin Tian
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Genomics
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007806
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