Can Resistin be a New Indicator of Neonatal Sepsis?
Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. T...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957213001034 |
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| author | Didem Aliefendioglu Tuğba Gürsoy Osman Çağlayan Alev Aktaş Fahri Ovalı |
| author_facet | Didem Aliefendioglu Tuğba Gürsoy Osman Çağlayan Alev Aktaş Fahri Ovalı |
| author_sort | Didem Aliefendioglu |
| collection | DOAJ |
| description | Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels of premature newborns with sepsis, which can also cause inflammatory response. The objective of this study was to evaluate whether resistin can be used as an indicator in neonatal sepsis of preterm babies.
Materials and methods: Forty-three premature newborns considered to have sepsis were included in the study. Forty-three gestational and postnatal age- and sex-matched premature newborns without premature prolonged rupture of membrane or sepsis served as controls.
Results: The median resistin and interleukin-6 (IL-6) levels of the premature babies with sepsis were 85.9 ng/mL and 342.7 pg/mL, respectively, and were higher than those of the control group (29.9 ng/mL and 17.7 pg/mL, respectively). The sensitivity, specificity, positive, and negative predictive values for resistin were 73.7%, 45.8%, 68.3%, and 52.4%, respectively.
Conclusion: Resistin levels were higher in premature newborns with sepsis and correlated with IL-6 levels, which is an indicator of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis. However, it has limited value when compared with the other inflammatory markers including C-reactive protein, procalcitonin, and IL-6. |
| format | Article |
| id | doaj-art-623b3152a7c548cbb3a2f11d1d0ba44c |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-623b3152a7c548cbb3a2f11d1d0ba44c2025-08-20T03:19:29ZengElsevierPediatrics and Neonatology1875-95722014-02-01551535710.1016/j.pedneo.2013.04.012Can Resistin be a New Indicator of Neonatal Sepsis?Didem Aliefendioglu0Tuğba Gürsoy1Osman Çağlayan2Alev Aktaş3Fahri Ovalı4Pediatrics and Biochemistry Department, Kırıkkale University Medical Faculty, Kırıkkale, TurkeyZeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, TurkeyPediatrics and Biochemistry Department, Kırıkkale University Medical Faculty, Kırıkkale, TurkeyZeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, TurkeyZeynep Kamil Maternity and Children's Education and Training Hospital, NICU, Istanbul, TurkeySepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels of premature newborns with sepsis, which can also cause inflammatory response. The objective of this study was to evaluate whether resistin can be used as an indicator in neonatal sepsis of preterm babies. Materials and methods: Forty-three premature newborns considered to have sepsis were included in the study. Forty-three gestational and postnatal age- and sex-matched premature newborns without premature prolonged rupture of membrane or sepsis served as controls. Results: The median resistin and interleukin-6 (IL-6) levels of the premature babies with sepsis were 85.9 ng/mL and 342.7 pg/mL, respectively, and were higher than those of the control group (29.9 ng/mL and 17.7 pg/mL, respectively). The sensitivity, specificity, positive, and negative predictive values for resistin were 73.7%, 45.8%, 68.3%, and 52.4%, respectively. Conclusion: Resistin levels were higher in premature newborns with sepsis and correlated with IL-6 levels, which is an indicator of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis. However, it has limited value when compared with the other inflammatory markers including C-reactive protein, procalcitonin, and IL-6.http://www.sciencedirect.com/science/article/pii/S1875957213001034C-reactive proteininterleukin-6prematureprocalcitoninresistinsepsis |
| spellingShingle | Didem Aliefendioglu Tuğba Gürsoy Osman Çağlayan Alev Aktaş Fahri Ovalı Can Resistin be a New Indicator of Neonatal Sepsis? Pediatrics and Neonatology C-reactive protein interleukin-6 premature procalcitonin resistin sepsis |
| title | Can Resistin be a New Indicator of Neonatal Sepsis? |
| title_full | Can Resistin be a New Indicator of Neonatal Sepsis? |
| title_fullStr | Can Resistin be a New Indicator of Neonatal Sepsis? |
| title_full_unstemmed | Can Resistin be a New Indicator of Neonatal Sepsis? |
| title_short | Can Resistin be a New Indicator of Neonatal Sepsis? |
| title_sort | can resistin be a new indicator of neonatal sepsis |
| topic | C-reactive protein interleukin-6 premature procalcitonin resistin sepsis |
| url | http://www.sciencedirect.com/science/article/pii/S1875957213001034 |
| work_keys_str_mv | AT didemaliefendioglu canresistinbeanewindicatorofneonatalsepsis AT tugbagursoy canresistinbeanewindicatorofneonatalsepsis AT osmancaglayan canresistinbeanewindicatorofneonatalsepsis AT alevaktas canresistinbeanewindicatorofneonatalsepsis AT fahriovalı canresistinbeanewindicatorofneonatalsepsis |