Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway

Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway

IntroductionOsteoarthritis in weight-bearing joints significantly impacts the quality of life in middle-aged and elderly individuals. Abnormal mechanical stress can induce chondrocytes ferroptosis, thereby accelerating the progression of osteoarthritis. In this study, we investigated the therapeutic...

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Bibliographic Details
Main Authors: Shaoyi Wang, Xiaocong Zhou, Fujian Zhang, Haoxin Zhai, Yuanqiang Zhang, Yongyuan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
ferroptosis
mechanical stress
THBS1
chondrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577234/full
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