MicroRNA‐204‐5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats

MicroRNA‐204‐5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats

Abstract Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural deterioration resulting in depression remain unclear. Here, it is found that miR‐204‐5p is mark...

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Main Authors: Xiao Chen, Yeting Gan, Kaiqi Zhang, Yuhan Wu, Ye Li, Tian Lan, Xianghua Zhuang, Shihong Chen, Shuyan Yu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
JAK2/STAT3 signaling pathway
MDD
miR‐204‐5p
neuroinflammation
neuronal apoptosis
synaptic plasticity
Online Access:https://doi.org/10.1002/advs.202403080
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