De novo transcriptome assembly of Acartia tonsa adults using Nanopore long-read sequencing

Abstract Acartia tonsa is a calanoid copepod with a cosmopolitan distribution. Its ecological relevance makes it a useful bioindicator organism for assessing the toxicity of various compounds. However, transcriptomic assemblies of A. tonsa using long-read technologies have not yet been described. Th...

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Bibliographic Details
Main Authors: Florencia Mohamed, Marco Picone, Greta Battaggia, Ilenia Urso, Elisa Camatti, Alessandro Vezzi, Gabriele Sales
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Data
Online Access:https://doi.org/10.1038/s41597-025-05399-6
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Summary:Abstract Acartia tonsa is a calanoid copepod with a cosmopolitan distribution. Its ecological relevance makes it a useful bioindicator organism for assessing the toxicity of various compounds. However, transcriptomic assemblies of A. tonsa using long-read technologies have not yet been described. The use of long-read sequencing technologies in transcriptomics allows the study of alternative splicing, structural variations and alternative polyadenylation sites. In this study, we present a de novo transcriptome of A. tonsa adult copepods exposed to different neonicotinoids obtained from Nanopore sequences. This transcriptome (261,560 total transcripts, with 31,291 representative sequences) exhibits 88.3% completeness and an N50 of 2,580 bases, showing better results than previous assemblies of the same organism. We also performed a full annotation by sequence homology (NR database), domain identification (InterProScan) and functional classification (Gene Ontology); 54.3% of representative transcripts were annotated in at least one database. Our transcriptome represents a solid baseline for further transcriptomic studies on A. tonsa and, specifically, its response to currently used pesticides.
ISSN:2052-4463