Neonatal Screening for Sickle Cell Disease in Congo
Introduction. Sickle cell disease is an autosomal recessive inherited disorder due to the mutation of a gene coding for the globin beta chain. The aim of this study is to update the epidemiological data on hemoglobinoses, in particular sickle cell disease in newborns in Congo. Materials and Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2022/9970315 |
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| author | Alexis Elira Dokekias Lethso Thibaut Ocko Gokaba Josué Simo Louokdom Lydie Ngolet Ocini Firmine Olivia Galiba Atipo Tsiba Coreillia Irène Ondzotto Ibatta Quentin Ngoma Kouandzi Serge Talomg Tamekue Jayne Chelsea Bango Jade Vanessa Nziengui Mboumba Simon Charles Kobawila |
| author_facet | Alexis Elira Dokekias Lethso Thibaut Ocko Gokaba Josué Simo Louokdom Lydie Ngolet Ocini Firmine Olivia Galiba Atipo Tsiba Coreillia Irène Ondzotto Ibatta Quentin Ngoma Kouandzi Serge Talomg Tamekue Jayne Chelsea Bango Jade Vanessa Nziengui Mboumba Simon Charles Kobawila |
| author_sort | Alexis Elira Dokekias |
| collection | DOAJ |
| description | Introduction. Sickle cell disease is an autosomal recessive inherited disorder due to the mutation of a gene coding for the globin beta chain. The aim of this study is to update the epidemiological data on hemoglobinoses, in particular sickle cell disease in newborns in Congo. Materials and Methods. This was a descriptive cross-sectional study, conducted from October 1, 2019, to March 31, 2020, throughout the Congolese national territory. It involved all full-term newborns, without distinction of nationality, aged 5 days or less, and whose parents consented to participate in the study. The blood samples, taken at the heel and collected on Whatman blotting paper, were analyzed using the HPLC Variant NBS machine. Results. In 2897 newborns (NN) screened, hemoglobin abnormalities were found in 603 NN (20.81%). The mean age of these newborns was 1 day (extremes 0 and 5 days). The male-to-female ratio was 1.03. Abnormal hemoglobins were mainly Hb S (n = 597 (97.71%)); Hb C (n = 5 (0.82%)); and variants (n = 7 (1.15%)). The national prevalence of major sickle cell (MSC) syndromes and sickle cell trait was 1.35% and 19.43%, respectively. The prevalence ranged from 1.77% to 2.56% for MSS in four departments and from 20.5% to 25.8% for the sickle cell trait in six other departments. Conclusion. Data on homozygous sickle cell disease remain consistent with previous studies. However, further studies should clarify the molecular anomalies of the variants observed in our samples. |
| format | Article |
| id | doaj-art-622b0e656f394510b353ff2eff1b4f10 |
| institution | Kabale University |
| issn | 2090-1275 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-622b0e656f394510b353ff2eff1b4f102025-08-20T03:34:53ZengWileyAnemia2090-12752022-01-01202210.1155/2022/9970315Neonatal Screening for Sickle Cell Disease in CongoAlexis Elira Dokekias0Lethso Thibaut Ocko Gokaba1Josué Simo Louokdom2Lydie Ngolet Ocini3Firmine Olivia Galiba Atipo Tsiba4Coreillia Irène Ondzotto Ibatta5Quentin Ngoma Kouandzi6Serge Talomg Tamekue7Jayne Chelsea Bango8Jade Vanessa Nziengui Mboumba9Simon Charles Kobawila10Centre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOCentre National de Référence de la Drépanocytose ‘’ Antoinette SASSOU N’GUESSOUniversité Marien NgouabiIntroduction. Sickle cell disease is an autosomal recessive inherited disorder due to the mutation of a gene coding for the globin beta chain. The aim of this study is to update the epidemiological data on hemoglobinoses, in particular sickle cell disease in newborns in Congo. Materials and Methods. This was a descriptive cross-sectional study, conducted from October 1, 2019, to March 31, 2020, throughout the Congolese national territory. It involved all full-term newborns, without distinction of nationality, aged 5 days or less, and whose parents consented to participate in the study. The blood samples, taken at the heel and collected on Whatman blotting paper, were analyzed using the HPLC Variant NBS machine. Results. In 2897 newborns (NN) screened, hemoglobin abnormalities were found in 603 NN (20.81%). The mean age of these newborns was 1 day (extremes 0 and 5 days). The male-to-female ratio was 1.03. Abnormal hemoglobins were mainly Hb S (n = 597 (97.71%)); Hb C (n = 5 (0.82%)); and variants (n = 7 (1.15%)). The national prevalence of major sickle cell (MSC) syndromes and sickle cell trait was 1.35% and 19.43%, respectively. The prevalence ranged from 1.77% to 2.56% for MSS in four departments and from 20.5% to 25.8% for the sickle cell trait in six other departments. Conclusion. Data on homozygous sickle cell disease remain consistent with previous studies. However, further studies should clarify the molecular anomalies of the variants observed in our samples.http://dx.doi.org/10.1155/2022/9970315 |
| spellingShingle | Alexis Elira Dokekias Lethso Thibaut Ocko Gokaba Josué Simo Louokdom Lydie Ngolet Ocini Firmine Olivia Galiba Atipo Tsiba Coreillia Irène Ondzotto Ibatta Quentin Ngoma Kouandzi Serge Talomg Tamekue Jayne Chelsea Bango Jade Vanessa Nziengui Mboumba Simon Charles Kobawila Neonatal Screening for Sickle Cell Disease in Congo Anemia |
| title | Neonatal Screening for Sickle Cell Disease in Congo |
| title_full | Neonatal Screening for Sickle Cell Disease in Congo |
| title_fullStr | Neonatal Screening for Sickle Cell Disease in Congo |
| title_full_unstemmed | Neonatal Screening for Sickle Cell Disease in Congo |
| title_short | Neonatal Screening for Sickle Cell Disease in Congo |
| title_sort | neonatal screening for sickle cell disease in congo |
| url | http://dx.doi.org/10.1155/2022/9970315 |
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