Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease
Disruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases. The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated with the intact regulation of the postsynaptic...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/2371970 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850157960081178624 |
|---|---|
| author | Holly Stefen Chanchanok Chaichim John Power Thomas Fath |
| author_facet | Holly Stefen Chanchanok Chaichim John Power Thomas Fath |
| author_sort | Holly Stefen |
| collection | DOAJ |
| description | Disruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases. The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated with the intact regulation of the postsynaptic cytoskeleton. In this review, we are discussing key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment. Special attention is given to the complex interplay of actin-associated proteins that are found in the synaptic specialization. We then discuss our current understanding of how disruption of these cytoskeletal elements may contribute to the pathological events observed in the nervous system under disease conditions with a particular focus on Alzheimer’s disease pathology. |
| format | Article |
| id | doaj-art-622ab47c228b4f5a842db2fa08ecf02b |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-622ab47c228b4f5a842db2fa08ecf02b2025-08-20T02:24:00ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/23719702371970Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in DiseaseHolly Stefen0Chanchanok Chaichim1John Power2Thomas Fath3Neurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaNeurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaTranslational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaNeurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaDisruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases. The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated with the intact regulation of the postsynaptic cytoskeleton. In this review, we are discussing key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment. Special attention is given to the complex interplay of actin-associated proteins that are found in the synaptic specialization. We then discuss our current understanding of how disruption of these cytoskeletal elements may contribute to the pathological events observed in the nervous system under disease conditions with a particular focus on Alzheimer’s disease pathology.http://dx.doi.org/10.1155/2016/2371970 |
| spellingShingle | Holly Stefen Chanchanok Chaichim John Power Thomas Fath Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease Neural Plasticity |
| title | Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease |
| title_full | Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease |
| title_fullStr | Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease |
| title_full_unstemmed | Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease |
| title_short | Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease |
| title_sort | regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease |
| url | http://dx.doi.org/10.1155/2016/2371970 |
| work_keys_str_mv | AT hollystefen regulationofthepostsynapticcompartmentofexcitatorysynapsesbytheactincytoskeletoninhealthanditsdisruptionindisease AT chanchanokchaichim regulationofthepostsynapticcompartmentofexcitatorysynapsesbytheactincytoskeletoninhealthanditsdisruptionindisease AT johnpower regulationofthepostsynapticcompartmentofexcitatorysynapsesbytheactincytoskeletoninhealthanditsdisruptionindisease AT thomasfath regulationofthepostsynapticcompartmentofexcitatorysynapsesbytheactincytoskeletoninhealthanditsdisruptionindisease |