Carrier-mediated transport as a common route of antibiotic ingress into bacteria

Carrier-mediated transport as a common route of antibiotic ingress into bacteria

ABSTRACT Among the most significant challenges in antibacterial discovery is achieving delivery of small molecule inhibitors across the bacterial membrane(s) to reach their intracellular targets. It is considered axiomatic that the typical route for antibiotics across the cytoplasmic membrane (CM) i...

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Bibliographic Details
Main Authors: Justin E. Clarke, Luiza H. Galarion, Abdulmenem A. Almadani, Christopher N. A. Smith, John D. Wright, Stuart L. Warriner, Alex J. O'Neill
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
antibiotic accumulation
drug uptake
transporters
import
importer
Online Access:https://journals.asm.org/doi/10.1128/mbio.01616-25
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