Altitude adaptation: The unseen work of gut microbiota
High altitudes are one type of extreme environment characterized by hypobaric hypoxia, extreme cold, strong ultraviolet radiation, and low energy availabilty that present tremendous challenges to human and wildlife inhabiting these environs. These extreme environments serve as a unique natural labor...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | hLife |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949928324000944 |
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| author | Jingling Guo Runzhou Zhao Kun Li Yafang Tan Likun Wang Hui Ling Huan Zhang Guha Dharmarajan Yujing Bi Ruifu Yang |
| author_facet | Jingling Guo Runzhou Zhao Kun Li Yafang Tan Likun Wang Hui Ling Huan Zhang Guha Dharmarajan Yujing Bi Ruifu Yang |
| author_sort | Jingling Guo |
| collection | DOAJ |
| description | High altitudes are one type of extreme environment characterized by hypobaric hypoxia, extreme cold, strong ultraviolet radiation, and low energy availabilty that present tremendous challenges to human and wildlife inhabiting these environs. These extreme environments serve as a unique natural laboratory for delving into the impact of selective pressures on species variation and adaptation. This narrative review compiles the latest research on high-altitude adaptation, with a specific focus on the crucial role of gut microbiota in this process. Evidence indicates that gut microbiota significantly impacts an organism's ability to adapt to high-altitude conditions by adjusting its composition, and hence impacting its function and ability to release microbial metabolites. We explore the link between gut microbiota and high-altitude environments, the microbial signatures, and their effects on adaptation, as well as the potential for targeted modulation of gut microbiota to enhance acclimatization to high altitudes. By examining the interaction between microbiota and host adaptation, this review aims to promote further mechanistic studies and support strategies for improving high-altitude acclimatization through gut microbiota modulation. |
| format | Article |
| id | doaj-art-6219df7f138a484ba12cb012c67b731a |
| institution | Kabale University |
| issn | 2949-9283 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | hLife |
| spelling | doaj-art-6219df7f138a484ba12cb012c67b731a2025-01-23T05:28:07ZengElsevierhLife2949-92832025-01-0131520Altitude adaptation: The unseen work of gut microbiotaJingling Guo0Runzhou Zhao1Kun Li2Yafang Tan3Likun Wang4Hui Ling5Huan Zhang6Guha Dharmarajan7Yujing Bi8Ruifu Yang9State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, ChinaSchool of Public Health, Hebei Medical University, Hebei, ChinaDivision of Sciences, School of Interwoven Arts and Sciences, Krea University, Andhra Pradesh, IndiaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China; Correspondence:State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China; School of Public Health, Hebei Medical University, Hebei, China; Correspondence:High altitudes are one type of extreme environment characterized by hypobaric hypoxia, extreme cold, strong ultraviolet radiation, and low energy availabilty that present tremendous challenges to human and wildlife inhabiting these environs. These extreme environments serve as a unique natural laboratory for delving into the impact of selective pressures on species variation and adaptation. This narrative review compiles the latest research on high-altitude adaptation, with a specific focus on the crucial role of gut microbiota in this process. Evidence indicates that gut microbiota significantly impacts an organism's ability to adapt to high-altitude conditions by adjusting its composition, and hence impacting its function and ability to release microbial metabolites. We explore the link between gut microbiota and high-altitude environments, the microbial signatures, and their effects on adaptation, as well as the potential for targeted modulation of gut microbiota to enhance acclimatization to high altitudes. By examining the interaction between microbiota and host adaptation, this review aims to promote further mechanistic studies and support strategies for improving high-altitude acclimatization through gut microbiota modulation.http://www.sciencedirect.com/science/article/pii/S2949928324000944plateaugut microbiotahypobaric hypoxiahighland exposureacclimatization |
| spellingShingle | Jingling Guo Runzhou Zhao Kun Li Yafang Tan Likun Wang Hui Ling Huan Zhang Guha Dharmarajan Yujing Bi Ruifu Yang Altitude adaptation: The unseen work of gut microbiota hLife plateau gut microbiota hypobaric hypoxia highland exposure acclimatization |
| title | Altitude adaptation: The unseen work of gut microbiota |
| title_full | Altitude adaptation: The unseen work of gut microbiota |
| title_fullStr | Altitude adaptation: The unseen work of gut microbiota |
| title_full_unstemmed | Altitude adaptation: The unseen work of gut microbiota |
| title_short | Altitude adaptation: The unseen work of gut microbiota |
| title_sort | altitude adaptation the unseen work of gut microbiota |
| topic | plateau gut microbiota hypobaric hypoxia highland exposure acclimatization |
| url | http://www.sciencedirect.com/science/article/pii/S2949928324000944 |
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