Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review)
Background. Osteoarthritis is a common chronic disease characterized by progressive degradation of all joint components and inflammation. The priority issue in the management of OA is searching for drugs that simultaneously relieve symptoms, modify the course of the disease, and are safe for use. S...
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Zaslavsky O.Yu.
2024-06-01
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| Series: | Bolʹ, Sustavy, Pozvonočnik |
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| Online Access: | https://pjs.zaslavsky.com.ua/index.php/journal/article/view/423 |
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| author | V.V. Cherniavskyi A.E. Baylo L.O. Onyshuk V.V. Tishchenko |
| author_facet | V.V. Cherniavskyi A.E. Baylo L.O. Onyshuk V.V. Tishchenko |
| author_sort | V.V. Cherniavskyi |
| collection | DOAJ |
| description | Background. Osteoarthritis is a common chronic disease characterized by progressive degradation of all joint components and inflammation. The priority issue in the management of OA is searching for drugs that simultaneously relieve symptoms, modify the course of the disease, and are safe for use. Symptomatic slow-acting drugs (SYSADOA) are of considerable interest due to their potential to slow cartilage degeneration and potential osteoarthritis disease modifying effect. The purpose of the study was to analyze current literature data on several types of SYSADOA, their biological role, mechanisms of effect on joints, effectiveness and safetye. Materials and methods. An analytical review of literature data was conducted using the analysis of scientific databases PubMed, Web of Science, Scopus, Google Scholar for the period 2005–2024, the search was conducted using the keywords “osteoarthritis”, “SYSADOA”, “DMOAD”, “effectiveness”, “safety”. Results. Glucosamine salts (GA) and chondroitin sulfate (CS) are the most studied slow-acting drugs and have positive biological effects on joint tissues. Prescription salts of GA and CS have effect of pain relieve and joint function improvement as separate agents and also potentiate the effect in combination. Studies revealed limiting of cartilage volume loss and joint space narrowing – a potential DMOAD effect of these drugs. GA salts and CS drugs are safe, as they have no difference in the frequency of side effects compared to placebo. The quality of drugs largely depends on the type of raw materials and technological production process, which are not standardized now. Conclusions. The role of SYSADOA in the treatment of OA has not been definitively determined, and studies on the effectiveness of drugs such as SYSADOA and the study of their DMOAD effect are still ongoing. Further studies should focus on the use of pharmacological class SYSADOA that have been properly purified and quality strictly supervised. |
| format | Article |
| id | doaj-art-6217ca4bb32a4809b61efab47d1ecad9 |
| institution | Kabale University |
| issn | 2224-1507 2307-1133 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Bolʹ, Sustavy, Pozvonočnik |
| spelling | doaj-art-6217ca4bb32a4809b61efab47d1ecad92024-11-10T19:56:08ZengZaslavsky O.Yu.Bolʹ, Sustavy, Pozvonočnik2224-15072307-11332024-06-011429610510.22141/pjs.14.2.2024.423423Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review)V.V. Cherniavskyi0https://orcid.org/0000-0001-5831-8810A.E. Baylo1https://orcid.org/0000-0003-3519-9788L.O. Onyshuk2https://orcid.org/0009-0005-9737-0423V.V. Tishchenko3https://orcid.org/0000-0002-4157-4428Bogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineBackground. Osteoarthritis is a common chronic disease characterized by progressive degradation of all joint components and inflammation. The priority issue in the management of OA is searching for drugs that simultaneously relieve symptoms, modify the course of the disease, and are safe for use. Symptomatic slow-acting drugs (SYSADOA) are of considerable interest due to their potential to slow cartilage degeneration and potential osteoarthritis disease modifying effect. The purpose of the study was to analyze current literature data on several types of SYSADOA, their biological role, mechanisms of effect on joints, effectiveness and safetye. Materials and methods. An analytical review of literature data was conducted using the analysis of scientific databases PubMed, Web of Science, Scopus, Google Scholar for the period 2005–2024, the search was conducted using the keywords “osteoarthritis”, “SYSADOA”, “DMOAD”, “effectiveness”, “safety”. Results. Glucosamine salts (GA) and chondroitin sulfate (CS) are the most studied slow-acting drugs and have positive biological effects on joint tissues. Prescription salts of GA and CS have effect of pain relieve and joint function improvement as separate agents and also potentiate the effect in combination. Studies revealed limiting of cartilage volume loss and joint space narrowing – a potential DMOAD effect of these drugs. GA salts and CS drugs are safe, as they have no difference in the frequency of side effects compared to placebo. The quality of drugs largely depends on the type of raw materials and technological production process, which are not standardized now. Conclusions. The role of SYSADOA in the treatment of OA has not been definitively determined, and studies on the effectiveness of drugs such as SYSADOA and the study of their DMOAD effect are still ongoing. Further studies should focus on the use of pharmacological class SYSADOA that have been properly purified and quality strictly supervised.https://pjs.zaslavsky.com.ua/index.php/journal/article/view/423osteoarthritissysadoadmoadeffectivenesssafetyqualityreview |
| spellingShingle | V.V. Cherniavskyi A.E. Baylo L.O. Onyshuk V.V. Tishchenko Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) Bolʹ, Sustavy, Pozvonočnik osteoarthritis sysadoa dmoad effectiveness safety quality review |
| title | Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) |
| title_full | Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) |
| title_fullStr | Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) |
| title_full_unstemmed | Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) |
| title_short | Critical evaluation of the current role of SYSADOA in the management of osteoarthritis (literature review) |
| title_sort | critical evaluation of the current role of sysadoa in the management of osteoarthritis literature review |
| topic | osteoarthritis sysadoa dmoad effectiveness safety quality review |
| url | https://pjs.zaslavsky.com.ua/index.php/journal/article/view/423 |
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