Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile
Purpose The Mayo Clinic Biobank was established to provide a large group of patients from which comparison groups (ie, controls) could be selected for case–control studies, to create a prospective cohort with sufficient power for common outcomes and to support electronic health record (EHR) studies....
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| Format: | Article |
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BMJ Publishing Group
2019-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/11/e032707.full |
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| author | Richard R Sharp Euijung Ryu Janet E Olson Matthew A Hathcock Ruchi Gupta Joshua T Bublitz Paul Y Takahashi Suzette J Bielinski Jennifer L St Sauver Karen Meagher Stephen N Thibodeau Mine Cicek James R Cerhan |
| author_facet | Richard R Sharp Euijung Ryu Janet E Olson Matthew A Hathcock Ruchi Gupta Joshua T Bublitz Paul Y Takahashi Suzette J Bielinski Jennifer L St Sauver Karen Meagher Stephen N Thibodeau Mine Cicek James R Cerhan |
| author_sort | Richard R Sharp |
| collection | DOAJ |
| description | Purpose The Mayo Clinic Biobank was established to provide a large group of patients from which comparison groups (ie, controls) could be selected for case–control studies, to create a prospective cohort with sufficient power for common outcomes and to support electronic health record (EHR) studies.Participants A total of 56 862 participants enrolled (21% response rate) into the Mayo Clinic Biobank from Rochester, Minnesota (77%, n=43 836), Jacksonville, Florida (18%, n=10 368) and La Crosse, Wisconsin (5%, n=2658). Participants were all Mayo Clinic patients, 18 years of age or older and US residents.Findings to date Overall, 43% of participants were 65 years of age or older and female participants were more frequent (59%) than males at all sites. Most participants resided in the Upper Midwest regions of the USA (Minnesota, Iowa, Illinois or Wisconsin), Florida or Georgia. Self-reported race among Biobank participants was 90% white. Here we provide examples of the types of studies that have successfully utilised the resource, including (1) investigations of the population itself, (2) provision of controls for case–control studies, (3) genotype-driven research, (4) EHR-based research and (5) prospective recruitment to other studies. Over 270 projects have been approved to date to access Biobank data and/or samples; over 200 000 sample aliquots have been approved for distribution.Future plans The data and samples in the Mayo Clinic Biobank can be used for various types of epidemiological and clinical studies, especially in the setting of case–control studies for which the Biobank samples serve as control samples. We are planning cohort studies with additional follow-up and acquisition of genetic information on a large scale. |
| format | Article |
| id | doaj-art-62151bb9ce3941fcb6307f7222278ac2 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-62151bb9ce3941fcb6307f7222278ac22024-11-29T12:50:10ZengBMJ Publishing GroupBMJ Open2044-60552019-11-0191110.1136/bmjopen-2019-032707Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profileRichard R Sharp0Euijung Ryu1Janet E Olson2Matthew A Hathcock3Ruchi Gupta4Joshua T Bublitz5Paul Y Takahashi6Suzette J Bielinski7Jennifer L St Sauver8Karen Meagher9Stephen N Thibodeau10Mine Cicek11James R Cerhan12Biomedical Ethics Research Program, Mayo Clinic, Rochester, Minnesota, USAComputational Biology, Mayo Clinic, Rochester, Minnesota, USADepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USADivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USADivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USADivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USADivision of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USADivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USADepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USABiomedical Ethics Research Program, Mayo Clinic, Rochester, Minnesota, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA3 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, NY, USAPurpose The Mayo Clinic Biobank was established to provide a large group of patients from which comparison groups (ie, controls) could be selected for case–control studies, to create a prospective cohort with sufficient power for common outcomes and to support electronic health record (EHR) studies.Participants A total of 56 862 participants enrolled (21% response rate) into the Mayo Clinic Biobank from Rochester, Minnesota (77%, n=43 836), Jacksonville, Florida (18%, n=10 368) and La Crosse, Wisconsin (5%, n=2658). Participants were all Mayo Clinic patients, 18 years of age or older and US residents.Findings to date Overall, 43% of participants were 65 years of age or older and female participants were more frequent (59%) than males at all sites. Most participants resided in the Upper Midwest regions of the USA (Minnesota, Iowa, Illinois or Wisconsin), Florida or Georgia. Self-reported race among Biobank participants was 90% white. Here we provide examples of the types of studies that have successfully utilised the resource, including (1) investigations of the population itself, (2) provision of controls for case–control studies, (3) genotype-driven research, (4) EHR-based research and (5) prospective recruitment to other studies. Over 270 projects have been approved to date to access Biobank data and/or samples; over 200 000 sample aliquots have been approved for distribution.Future plans The data and samples in the Mayo Clinic Biobank can be used for various types of epidemiological and clinical studies, especially in the setting of case–control studies for which the Biobank samples serve as control samples. We are planning cohort studies with additional follow-up and acquisition of genetic information on a large scale.https://bmjopen.bmj.com/content/9/11/e032707.full |
| spellingShingle | Richard R Sharp Euijung Ryu Janet E Olson Matthew A Hathcock Ruchi Gupta Joshua T Bublitz Paul Y Takahashi Suzette J Bielinski Jennifer L St Sauver Karen Meagher Stephen N Thibodeau Mine Cicek James R Cerhan Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile BMJ Open |
| title | Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile |
| title_full | Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile |
| title_fullStr | Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile |
| title_full_unstemmed | Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile |
| title_short | Characteristics and utilisation of the Mayo Clinic Biobank, a clinic-based prospective collection in the USA: cohort profile |
| title_sort | characteristics and utilisation of the mayo clinic biobank a clinic based prospective collection in the usa cohort profile |
| url | https://bmjopen.bmj.com/content/9/11/e032707.full |
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