The inoculum dose of Zika virus can affect the viral replication dynamics, cytokine responses and survival rate in immunocompromised AG129 mice

The inoculum dose of Zika virus can affect the viral replication dynamics, cytokine responses and survival rate in immunocompromised AG129 mice

Abstract Zika virus, a mosquito-borne arbovirus, has repeatedly caused large pandemics with symptoms worsening from mild and self-limiting diseases to Guillain–Barré syndrome in adults and fetal microcephaly in newborns. In recent years, Zika virus diseases have posed a serious threat to human healt...

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Bibliographic Details
Main Authors: Yuhuan Yan, Hao Yang, Yun Yang, Junbin Wang, Yanan Zhou, Cong Tang, Bai Li, Qing Huang, Ran An, Xiaoming Liang, Dongdong Lin, Wenhai Yu, Changfa Fan, Shuaiyao Lu
Format: Article
Language:English
Published: Springer 2024-08-01
Series:Molecular Biomedicine
Subjects:
Zika virus
AG129 mouse
Replication dynamics
Tissue tropism
Pathological lesion
Cytokine
Online Access:https://doi.org/10.1186/s43556-024-00195-x
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