In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone

Polyether ether ketone (PEEK) is considered the best alternative material for titanium for spinal fusion cage implants due to its low elasticity modulus and radiolucent property. The main problem of PEEK is its bioinert properties. Coating with hydroxyapatite (HA) showed very good improvement in bio...

Full description

Saved in:
Bibliographic Details
Main Authors: D. Almasi, S. Izman, M. Sadeghi, N. Iqbal, F. Roozbahani, G. Krishnamurithy, T. Kamarul, M. R. Abdul Kadir
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:International Journal of Biomaterials
Online Access:http://dx.doi.org/10.1155/2015/475435
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832549655587586048
author D. Almasi
S. Izman
M. Sadeghi
N. Iqbal
F. Roozbahani
G. Krishnamurithy
T. Kamarul
M. R. Abdul Kadir
author_facet D. Almasi
S. Izman
M. Sadeghi
N. Iqbal
F. Roozbahani
G. Krishnamurithy
T. Kamarul
M. R. Abdul Kadir
author_sort D. Almasi
collection DOAJ
description Polyether ether ketone (PEEK) is considered the best alternative material for titanium for spinal fusion cage implants due to its low elasticity modulus and radiolucent property. The main problem of PEEK is its bioinert properties. Coating with hydroxyapatite (HA) showed very good improvement in bioactivity of the PEEK implants. However the existing methods for deposition of HA have some disadvantages and damage the PEEK substrate. In our previous study a new method for deposition of HA on PEEK was presented. In this study cell proliferation of mesenchymal stem cell and apatite formation in simulated body fluid (SBF) tests were conducted to probe the effect of this new method in improvement of the bioactivity of PEEK. The mesenchymal stem cell proliferation result showed better cells proliferation on the treated layer in comparison with untreated PEEK. The apatite formation results showed the growth of the HA on the treated PEEK but there was not any sight of the growth of HA on the untreated PEEK even after 2 weeks. The results showed the new method of the HA deposition improved the bioactivity of the treated PEEK in comparison with the bare PEEK.
format Article
id doaj-art-620ff7aed38542b9a99efa9e9911e1a5
institution Kabale University
issn 1687-8787
1687-8795
language English
publishDate 2015-01-01
publisher Wiley
record_format Article
series International Journal of Biomaterials
spelling doaj-art-620ff7aed38542b9a99efa9e9911e1a52025-02-03T06:10:48ZengWileyInternational Journal of Biomaterials1687-87871687-87952015-01-01201510.1155/2015/475435475435In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether KetoneD. Almasi0S. Izman1M. Sadeghi2N. Iqbal3F. Roozbahani4G. Krishnamurithy5T. Kamarul6M. R. Abdul Kadir7Department of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaDepartment of Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaFaculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, MalaysiaMedical Devices & Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaFaculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaInstitute of Translational Medicine, University of Liverpool, Sherrington Building, Liverpool L69 3GE, UKDepartment of Orthopaedic Surgery, NOCERAL, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaMedical Devices & Technology Group (MEDITEG), Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, MalaysiaPolyether ether ketone (PEEK) is considered the best alternative material for titanium for spinal fusion cage implants due to its low elasticity modulus and radiolucent property. The main problem of PEEK is its bioinert properties. Coating with hydroxyapatite (HA) showed very good improvement in bioactivity of the PEEK implants. However the existing methods for deposition of HA have some disadvantages and damage the PEEK substrate. In our previous study a new method for deposition of HA on PEEK was presented. In this study cell proliferation of mesenchymal stem cell and apatite formation in simulated body fluid (SBF) tests were conducted to probe the effect of this new method in improvement of the bioactivity of PEEK. The mesenchymal stem cell proliferation result showed better cells proliferation on the treated layer in comparison with untreated PEEK. The apatite formation results showed the growth of the HA on the treated PEEK but there was not any sight of the growth of HA on the untreated PEEK even after 2 weeks. The results showed the new method of the HA deposition improved the bioactivity of the treated PEEK in comparison with the bare PEEK.http://dx.doi.org/10.1155/2015/475435
spellingShingle D. Almasi
S. Izman
M. Sadeghi
N. Iqbal
F. Roozbahani
G. Krishnamurithy
T. Kamarul
M. R. Abdul Kadir
In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
International Journal of Biomaterials
title In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
title_full In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
title_fullStr In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
title_full_unstemmed In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
title_short In Vitro Evaluation of Bioactivity of Chemically Deposited Hydroxyapatite on Polyether Ether Ketone
title_sort in vitro evaluation of bioactivity of chemically deposited hydroxyapatite on polyether ether ketone
url http://dx.doi.org/10.1155/2015/475435
work_keys_str_mv AT dalmasi invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT sizman invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT msadeghi invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT niqbal invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT froozbahani invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT gkrishnamurithy invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT tkamarul invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone
AT mrabdulkadir invitroevaluationofbioactivityofchemicallydepositedhydroxyapatiteonpolyetheretherketone