Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults

BackgroundThe Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions...

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Main Authors: R. Mohamad Javier, Stephanie Angela Prijanto, Vallexa Septina Yora, Desak Gede Yuliana Eka Pratiwi, Errini Sabilla Lilhawa Ditsi, Bella Adelia, Verika Christabela Tansuri, Hendry Wijaya, Georaldhy Yussufy Caecarma, Intan Trikumala Damayanti, Anisa Ramadhanti, Atika Rahmaputri, Chabib Fachry Albab, Afif Ferdian, Fatih Farabi, Fadila Risang Ayu, Ni Putu Ika Regina Maharani, Andika Prasetyo Arifin, Eko Setyo Herwanto, Saidah Rahmat A, Safira Dita Arviana, Syifa Nur Lathifah, Nanda Rizki Yulinar, Laksmitha Saktiono Safitri, Basyar Adnani, M. Rizki Fazrian Danu, Natasya Naomi, Dayu Dwi Deria, Aulia Syifa, Panca Andana, Adrian Prasetya, Fachira Rachel Agfata, Magistra Cylvia Margaretha, Subandono Bambang Indrasto, Sukirman, Rachmanto, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch Aleq Sander
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Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cardiovascular Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1505298/full
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author R. Mohamad Javier
Stephanie Angela Prijanto
Vallexa Septina Yora
Desak Gede Yuliana Eka Pratiwi
Errini Sabilla Lilhawa Ditsi
Bella Adelia
Verika Christabela Tansuri
Hendry Wijaya
Georaldhy Yussufy Caecarma
Intan Trikumala Damayanti
Anisa Ramadhanti
Atika Rahmaputri
Chabib Fachry Albab
Afif Ferdian
Fatih Farabi
Fadila Risang Ayu
Ni Putu Ika Regina Maharani
Andika Prasetyo Arifin
Eko Setyo Herwanto
Saidah Rahmat A
Safira Dita Arviana
Syifa Nur Lathifah
Nanda Rizki Yulinar
Laksmitha Saktiono Safitri
Basyar Adnani
M. Rizki Fazrian Danu
Natasya Naomi
Dayu Dwi Deria
Aulia Syifa
Panca Andana
Adrian Prasetya
Fachira Rachel Agfata
Magistra Cylvia Margaretha
Subandono Bambang Indrasto
Sukirman
Rachmanto
Hayatun Nufus
Pertiwi Febriana Chandrawati
Aan Dwi Prasetyo
Lucky Sutanto
Moch Aleq Sander
author_facet R. Mohamad Javier
Stephanie Angela Prijanto
Vallexa Septina Yora
Desak Gede Yuliana Eka Pratiwi
Errini Sabilla Lilhawa Ditsi
Bella Adelia
Verika Christabela Tansuri
Hendry Wijaya
Georaldhy Yussufy Caecarma
Intan Trikumala Damayanti
Anisa Ramadhanti
Atika Rahmaputri
Chabib Fachry Albab
Afif Ferdian
Fatih Farabi
Fadila Risang Ayu
Ni Putu Ika Regina Maharani
Andika Prasetyo Arifin
Eko Setyo Herwanto
Saidah Rahmat A
Safira Dita Arviana
Syifa Nur Lathifah
Nanda Rizki Yulinar
Laksmitha Saktiono Safitri
Basyar Adnani
M. Rizki Fazrian Danu
Natasya Naomi
Dayu Dwi Deria
Aulia Syifa
Panca Andana
Adrian Prasetya
Fachira Rachel Agfata
Magistra Cylvia Margaretha
Subandono Bambang Indrasto
Sukirman
Rachmanto
Hayatun Nufus
Pertiwi Febriana Chandrawati
Aan Dwi Prasetyo
Lucky Sutanto
Moch Aleq Sander
author_sort R. Mohamad Javier
collection DOAJ
description BackgroundThe Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients.MethodsThis review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications.ResultThe study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases.ConclusionMPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications.
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spelling doaj-art-620bceef62cc400f96d7c620ee4a35cc2025-01-29T13:25:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.15052981505298Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adultsR. Mohamad Javier0Stephanie Angela Prijanto1Vallexa Septina Yora2Desak Gede Yuliana Eka Pratiwi3Errini Sabilla Lilhawa Ditsi4Bella Adelia5Verika Christabela Tansuri6Hendry Wijaya7Georaldhy Yussufy Caecarma8Intan Trikumala Damayanti9Anisa Ramadhanti10Atika Rahmaputri11Chabib Fachry Albab12Afif Ferdian13Fatih Farabi14Fadila Risang Ayu15Ni Putu Ika Regina Maharani16Andika Prasetyo Arifin17Eko Setyo Herwanto18Saidah Rahmat A19Safira Dita Arviana20Syifa Nur Lathifah21Nanda Rizki Yulinar22Laksmitha Saktiono Safitri23Basyar Adnani24M. Rizki Fazrian Danu25Natasya Naomi26Dayu Dwi Deria27Aulia Syifa28Panca Andana29Adrian Prasetya30Fachira Rachel Agfata31Magistra Cylvia Margaretha32Subandono Bambang Indrasto33 Sukirman34 Rachmanto35Hayatun Nufus36Pertiwi Febriana Chandrawati37Aan Dwi Prasetyo38Lucky Sutanto39Moch Aleq Sander40Department of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaFaculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Brawijaya Univeristy, Malang, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Pelita Harapan University, Tangerang, IndonesiaFaculty of Medicine, Atma Jaya Indonesian Catholic University, Jakarta, IndonesiaFaculty of Medicine, Airlangga University, Surabaya, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Airlangga University, Surabaya, IndonesiaDepartment of Internal Medicine, Permata Bunda Hospital, Malang, IndonesiaDepartment of Internal Medicine, Heartology Cardiovascular Hospital, Jakarta, Indonesia0Faculty of Medicine, Diponegoro University, Semarang, Indonesia1Faculty of Medicine, Hang Tuah Surabaya University, Surabaya, Indonesia2Faculty of Medicine, Krida Wacana Christian University, Jakarta, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, Indonesia3Faculty of Medicine, Maulana Malik Ibrahim Malang University, Malang, Indonesia4Department of Internal Medicine, Bayu Asih Purwakarta Hospital, Purwakarta, Indonesia5Faculty of Medicine, Jember University, Jember, IndonesiaFaculty of Medicine, Muhammadiyah Malang University, Malang, Indonesia3Faculty of Medicine, Maulana Malik Ibrahim Malang University, Malang, Indonesia6Faculty of Medicine, Malikussaleh University, Aceh, Indonesia7Faculty of Medicine, Islamic University of Indonesia, Yogyakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, Indonesia8Department of Opthalmology, Gatot Soebroto Army Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Gatot Soebroto Army Hospital, Jakarta, Indonesia9Department of Pediatric, Gatot Soebroto Army Hospital, Jakarta, Indonesia0Department of Internal Medicine, Persahabatan Hospital, Jakarta, Indonesia1Department of Pediatric, Muhammadiyah Malang University Hospital, Malang, Indonesia2Department of Neurology, Muhammadiyah Malang University Hospital, Malang, Indonesia3Department of Obstetrics and Gynecology, Kartika Husada Tanjungpura, Tanjungpura, Indonesia4Department of Surgery, Muhammadiyah Malang University Hospital, Malang, IndonesiaBackgroundThe Monkeypox Virus (MPOX) has caused a surge in viral infections, leading to the WHO recognizing it as a public health emergency of international concern. MPOX infection shares clinical similarities with smallpox but can cause complications like myocarditis, anorectal pain, ocular lesions, kidney damage, or soft tissue superinfection. The study aims to understand the characteristics of myocarditis, fixed drug eruption, and dry eye syndrome in Monkeypox patients.MethodsThis review was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions. The data was obtained from Scopus and international journal databases by conducting combined keyword searches restricted to English-language publications.ResultThe study examined 25 cases of Monkeypox, primarily involving males aged 32.9 years and experiencing chest pain. The prognosis was generally good, with no reported death. Risk factors for infection include sexual activity, STD diagnosis, sexual encounters, and workplace exposure to orthopoxviruses. Most cases were male and involved chest pain. Myocarditis, an inflammation in the myocardium, can cause dilated cardiomyopathy, acute arrhythmia, and heart failure. The pathophysiology of myocarditis in Monkeypox patients is not yet determined due to rarity of cases.ConclusionMPOX infection presents unique complications like myocarditis, necessitating research for vaccines, antiviral drugs, and infection prevention measures. Early screening for chest pain and investigating MPXV infection's pathogenesis and clinical features are crucial for differential diagnosis during outbreaks. This systematic review can determine MPOX infection outcomes and prepare appropriate treatment for patients with complications.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1505298/fullmonkeypoxmyocarditisdry eye syndromefixed drug eruptionMPOX vaccinationcharacteristics
spellingShingle R. Mohamad Javier
Stephanie Angela Prijanto
Vallexa Septina Yora
Desak Gede Yuliana Eka Pratiwi
Errini Sabilla Lilhawa Ditsi
Bella Adelia
Verika Christabela Tansuri
Hendry Wijaya
Georaldhy Yussufy Caecarma
Intan Trikumala Damayanti
Anisa Ramadhanti
Atika Rahmaputri
Chabib Fachry Albab
Afif Ferdian
Fatih Farabi
Fadila Risang Ayu
Ni Putu Ika Regina Maharani
Andika Prasetyo Arifin
Eko Setyo Herwanto
Saidah Rahmat A
Safira Dita Arviana
Syifa Nur Lathifah
Nanda Rizki Yulinar
Laksmitha Saktiono Safitri
Basyar Adnani
M. Rizki Fazrian Danu
Natasya Naomi
Dayu Dwi Deria
Aulia Syifa
Panca Andana
Adrian Prasetya
Fachira Rachel Agfata
Magistra Cylvia Margaretha
Subandono Bambang Indrasto
Sukirman
Rachmanto
Hayatun Nufus
Pertiwi Febriana Chandrawati
Aan Dwi Prasetyo
Lucky Sutanto
Moch Aleq Sander
Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
Frontiers in Cardiovascular Medicine
monkeypox
myocarditis
dry eye syndrome
fixed drug eruption
MPOX vaccination
characteristics
title Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
title_full Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
title_fullStr Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
title_full_unstemmed Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
title_short Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
title_sort systematic review characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults
topic monkeypox
myocarditis
dry eye syndrome
fixed drug eruption
MPOX vaccination
characteristics
url https://www.frontiersin.org/articles/10.3389/fcvm.2024.1505298/full
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