Effects of the Bacterial Extract OM-85 on Phagocyte Functions and the Stress Response
The effects of the bacterial extract OM-85 on the respiratory burst, intracellular calcium and the stress response have been investigated in human peripheral blood monocytes from normal donors. Activation of the respiratory burst during bacterial phagocytosis has been previously associated with heat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000189 |
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| Summary: | The effects of the bacterial extract OM-85 on the respiratory burst,
intracellular calcium and the stress response have been investigated
in human peripheral blood monocytes from normal donors. Activation
of the respiratory burst during bacterial phagocytosis has been
previously associated with heat shock/stress proteins synthesis.
Whereas OM-85 stimulated superoxide production and increased
Ca2+ mobilization, it fared to induce synthesis of
classical HSPs. The lack of stress protein induction was observed
even in the presence of iron which potentiates both oxidative injury
and stress protein induction during bacterial phagocytosis. However
OM-85 induced a 75–78 kDa protein, which is likely to be a
glucose regulated protein (GRP78), and enhanced intracellular
expression of interleukin-lβ precursor. |
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| ISSN: | 0962-9351 1466-1861 |