Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies

Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies

Calcium ions play a crucial role in cardiac excitation-contraction (EC) coupling, and disruptions in Ca2+ homeostasis are a key factor in the development of dilated cardiomyopathy (DCM). This review aims to systematically analyze how structural and functional remodeling of Ca2+-handling proteins dri...

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Main Authors: Yuhan Wang, Tingting Zhou, Jiajing Zhao, Hongjun Zhu, Xiaodong Tan, Jiahao Chen, Zhuojun Zhang, Lijuan Shen, Shu Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Channels
Subjects:
Dilated cardiomyopathy
calcium signaling
Ca2+ handling
calcium-induced calcium release
Dictionary”>sarcoplasmic reticulum Ca2+ -ATPase
phospholamban
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2025.2519545
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https://www.tandfonline.com/doi/10.1080/19336950.2025.2519545

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