Transgelin-2: A potential oncogenic factor
Actin-binding proteins are proteins that could bind to actin or actin fibers. As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2 , is differently expressed in all cells and tissues. The deregulation of Transgelin-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-06-01
|
| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317702650 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849416350252924928 |
|---|---|
| author | Ti Meng Leichao Liu Ruifang Hao Siying Chen Yalin Dong |
| author_facet | Ti Meng Leichao Liu Ruifang Hao Siying Chen Yalin Dong |
| author_sort | Ti Meng |
| collection | DOAJ |
| description | Actin-binding proteins are proteins that could bind to actin or actin fibers. As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2 , is differently expressed in all cells and tissues. The deregulation of Transgelin-2 is considered to be correlated with progression of many kinds of diseases, especially the development of malignant tumors, such as invasion, metastasis, and resistance, yet the function and mechanism of action of Transgelin-2 remain elusive. Therefore, we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development. |
| format | Article |
| id | doaj-art-61fb44c08a3f486e9dec12abf3bcf613 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-61fb44c08a3f486e9dec12abf3bcf6132025-08-20T03:33:13ZengSAGE PublishingTumor Biology1423-03802017-06-013910.1177/1010428317702650Transgelin-2: A potential oncogenic factorTi MengLeichao LiuRuifang HaoSiying ChenYalin DongActin-binding proteins are proteins that could bind to actin or actin fibers. As a member of actin-binding proteins, Transgelin-2 is expressed in smooth muscle cells and non-smooth muscle cells, and its gene, TAGLN2 , is differently expressed in all cells and tissues. The deregulation of Transgelin-2 is considered to be correlated with progression of many kinds of diseases, especially the development of malignant tumors, such as invasion, metastasis, and resistance, yet the function and mechanism of action of Transgelin-2 remain elusive. Therefore, we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development.https://doi.org/10.1177/1010428317702650 |
| spellingShingle | Ti Meng Leichao Liu Ruifang Hao Siying Chen Yalin Dong Transgelin-2: A potential oncogenic factor Tumor Biology |
| title | Transgelin-2: A potential oncogenic factor |
| title_full | Transgelin-2: A potential oncogenic factor |
| title_fullStr | Transgelin-2: A potential oncogenic factor |
| title_full_unstemmed | Transgelin-2: A potential oncogenic factor |
| title_short | Transgelin-2: A potential oncogenic factor |
| title_sort | transgelin 2 a potential oncogenic factor |
| url | https://doi.org/10.1177/1010428317702650 |
| work_keys_str_mv | AT timeng transgelin2apotentialoncogenicfactor AT leichaoliu transgelin2apotentialoncogenicfactor AT ruifanghao transgelin2apotentialoncogenicfactor AT siyingchen transgelin2apotentialoncogenicfactor AT yalindong transgelin2apotentialoncogenicfactor |