Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia

Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia

Background: Acute myeloid leukemia (AML) is a common and aggressive form of leukemia, yet current treatment strategies remain insufficient. Venetoclax, a BH3-mimetic approved for AML treatment, induces Bcl-2-dependent apoptosis, though its therapeutic efficacy is still limited. Therefore, new strate...

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Bibliographic Details
Main Authors: Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Diseases
Subjects:
acute myeloid leukemia
valproic acid
apoptosis
Bcl-2
Bax
Bak
Online Access:https://www.mdpi.com/2079-9721/13/1/10
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