The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy
Aim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2011-09-01
|
| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6222 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849729951113150464 |
|---|---|
| author | Tatiana Nikolaevna Kochegura Zhanna Alekseevna Akopyan Georgy Vladimirovich Sharonov Anastasia Yur'evna Efimenko Fail' Taipovich Ageev Artem Germanovich Ovchinnikov Lyudmila Vital'evna Zhigunova Elena Leonidovna Lakhova Boris Dmitrievich Kulev Angelina Vladimirovna Sokolova Marina Vladimirovna Shestakova Elena Viktorovna Parfenova |
| author_facet | Tatiana Nikolaevna Kochegura Zhanna Alekseevna Akopyan Georgy Vladimirovich Sharonov Anastasia Yur'evna Efimenko Fail' Taipovich Ageev Artem Germanovich Ovchinnikov Lyudmila Vital'evna Zhigunova Elena Leonidovna Lakhova Boris Dmitrievich Kulev Angelina Vladimirovna Sokolova Marina Vladimirovna Shestakova Elena Viktorovna Parfenova |
| author_sort | Tatiana Nikolaevna Kochegura |
| collection | DOAJ |
| description | Aim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in 47 patients with CHD including 14 with CHD + DM2; 12patients without CHD and DM2 made up the control grouP. Enzyme-linked immunosorbent assay was used to measure N-terminal precursor of brainnatriuretic peptide (NT-proBNP), immunoreactive insulin (IRI) and C-peptide levels. Results. The number of CPC in patients with ischemic cardiomyopathy without DM2 was 33.4% greater than in controls. In patients with cardiomyopathyand DM2 the number of CPC depended on the quality of diabetes compensation. It was lowest in case of decompensated DM2 (HbA1c=9.5?1.8%).In patients with compensated/subcompensated DM2 (HbA1c=6.8?0.3%) it was significantly higher than in controls and patients with ischemiccardiomyopathy without DM2 (mean 46.5 (p=0.006) and 40.0% (p=0.02) respectively). Conclusion. The number of CPC in peripheral blood of patients with ischemic cardiomyopathy and DM2 correlated with the level of DM compensation.It was lowest in patients with decompensated DM2 and exceeded the normal number in patients with CHD without DM2. The number of CPC inverselycorrelated with blood glucose level. Positive correlation of CPC number with IRI and C-peptide levels was documented in control subjects and patientswith CHD without DM2. |
| format | Article |
| id | doaj-art-61e853b4c0c6425c8277f219f4e3a2b6 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2011-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-61e853b4c0c6425c8277f219f4e3a2b62025-08-20T03:09:01ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782011-09-01143364310.14341/2072-0351-62226180The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathyTatiana Nikolaevna Kochegura0Zhanna Alekseevna Akopyan1Georgy Vladimirovich Sharonov2Anastasia Yur'evna Efimenko3Fail' Taipovich Ageev4Artem Germanovich Ovchinnikov5Lyudmila Vital'evna Zhigunova6Elena Leonidovna Lakhova7Boris Dmitrievich Kulev8Angelina Vladimirovna Sokolova9Marina Vladimirovna Shestakova10Elena Viktorovna Parfenova11M.V.Lomonosov Moscow State University, MoscowM.V.Lomonosov Moscow State University, MoscowM.V.Lomonosov Moscow State University, MoscowM.V.Lomonosov Moscow State University, MoscowRussian Cardiological Research and Production Complex, MoscowRussian Cardiological Research and Production Complex, MoscowRussian Cardiological Research and Production Complex, MoscowRussian Cardiological Research and Production Complex, MoscowRussian Cardiological Research and Production Complex, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAim. To study effect of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells (CPC) in patients with coronary heart disease(CHD) and postinfarction heart failure (ischemic cardiomyopathy).Methods. The number of CPC (CD34+ cells) was determined by flow cytophotometry in 47 patients with CHD including 14 with CHD + DM2; 12patients without CHD and DM2 made up the control grouP. Enzyme-linked immunosorbent assay was used to measure N-terminal precursor of brainnatriuretic peptide (NT-proBNP), immunoreactive insulin (IRI) and C-peptide levels. Results. The number of CPC in patients with ischemic cardiomyopathy without DM2 was 33.4% greater than in controls. In patients with cardiomyopathyand DM2 the number of CPC depended on the quality of diabetes compensation. It was lowest in case of decompensated DM2 (HbA1c=9.5?1.8%).In patients with compensated/subcompensated DM2 (HbA1c=6.8?0.3%) it was significantly higher than in controls and patients with ischemiccardiomyopathy without DM2 (mean 46.5 (p=0.006) and 40.0% (p=0.02) respectively). Conclusion. The number of CPC in peripheral blood of patients with ischemic cardiomyopathy and DM2 correlated with the level of DM compensation.It was lowest in patients with decompensated DM2 and exceeded the normal number in patients with CHD without DM2. The number of CPC inverselycorrelated with blood glucose level. Positive correlation of CPC number with IRI and C-peptide levels was documented in control subjects and patientswith CHD without DM2.https://www.dia-endojournals.ru/jour/article/view/6222circulating progenitor cellstype 2 diabetescoronary heart disease |
| spellingShingle | Tatiana Nikolaevna Kochegura Zhanna Alekseevna Akopyan Georgy Vladimirovich Sharonov Anastasia Yur'evna Efimenko Fail' Taipovich Ageev Artem Germanovich Ovchinnikov Lyudmila Vital'evna Zhigunova Elena Leonidovna Lakhova Boris Dmitrievich Kulev Angelina Vladimirovna Sokolova Marina Vladimirovna Shestakova Elena Viktorovna Parfenova The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy Сахарный диабет circulating progenitor cells type 2 diabetes coronary heart disease |
| title | The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| title_full | The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| title_fullStr | The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| title_full_unstemmed | The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| title_short | The influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| title_sort | influence of concomitant type 2 diabetes mellitus on the number of circulating progenitor cells in patients with ischemiccardiomyopathy |
| topic | circulating progenitor cells type 2 diabetes coronary heart disease |
| url | https://www.dia-endojournals.ru/jour/article/view/6222 |
| work_keys_str_mv | AT tatiananikolaevnakochegura theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT zhannaalekseevnaakopyan theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT georgyvladimirovichsharonov theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT anastasiayurevnaefimenko theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT failtaipovichageev theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT artemgermanovichovchinnikov theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT lyudmilavitalevnazhigunova theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT elenaleonidovnalakhova theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT borisdmitrievichkulev theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT angelinavladimirovnasokolova theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT marinavladimirovnashestakova theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT elenaviktorovnaparfenova theinfluenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT tatiananikolaevnakochegura influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT zhannaalekseevnaakopyan influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT georgyvladimirovichsharonov influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT anastasiayurevnaefimenko influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT failtaipovichageev influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT artemgermanovichovchinnikov influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT lyudmilavitalevnazhigunova influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT elenaleonidovnalakhova influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT borisdmitrievichkulev influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT angelinavladimirovnasokolova influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT marinavladimirovnashestakova influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy AT elenaviktorovnaparfenova influenceofconcomitanttype2diabetesmellitusonthenumberofcirculatingprogenitorcellsinpatientswithischemiccardiomyopathy |