Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis

Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis

Abstract Background Periodontitis is a chronic inflammatory disease and macrophages play a pivotal role in the progression of periodontitis. Mesenchymal stem cells (MSCs) have emerged as potential therapeutic agents for the treatment of periodontitis due to their immunomodulatory properties and capa...

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Bibliographic Details
Main Authors: Liang Chen, Yuanqing Liu, Chenhao Yu, Pei Cao, Yiming Ma, Yiran Geng, Yu Cai, Yong Zhang, Jia Liu, Yang Li, Qingxian Luan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Induced pluripotent stem cells
Mesenchymal stem cells
Macrophage polarization
Periodontitis
NF-κB signaling pathway
Alveolar bone loss
Online Access:https://doi.org/10.1186/s13287-025-04327-0
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