Multi‐Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals

Multi‐Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals

Background Although utility of composite trait‐specific polygenic risk score (multi‐trait PRS) has been examined among European ancestries, few studies investigated among East Asians and incorporated modifiable risk factors. We examined the associations of multi‐trait PRS for cardiometabolic factors...

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Main Authors: Ryosuke Fujii, Mako Nagayoshi, Masahiro Nakatochi, Shuntaro Sato, Yoshiki Tsuboi, Koji Suzuki, Hiroaki Ikezaki, Yuichiro Nishida, Yoko Kubo, Shiroh Tanoue, Sadao Suzuki, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Sakurako Katsuura‐Kamano, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiovascular disease
genetic epidemiology
genome‐wide association study
nongenetic determinants
polygenic risk score
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.038572
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