Unraveling Dowling–Degos Disease: A Rare Skin Disorder
ABSTRACT Dowling–Degos disease (DDD) is a rare genodermatosis characterized by brown to black macules distributed symmetrically in the axilla, groin, elbow, face, neck, and trunk. It is more common in women, usually after puberty. The main pathogenesis behind DDD is a mutation in the keratin 5 gene....
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70643 |
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| author | Mahesh Mathur Neha Thakur Supriya Paudel Sambidha Karki Sandhya Regmi Nabita Bhattarai |
| author_facet | Mahesh Mathur Neha Thakur Supriya Paudel Sambidha Karki Sandhya Regmi Nabita Bhattarai |
| author_sort | Mahesh Mathur |
| collection | DOAJ |
| description | ABSTRACT Dowling–Degos disease (DDD) is a rare genodermatosis characterized by brown to black macules distributed symmetrically in the axilla, groin, elbow, face, neck, and trunk. It is more common in women, usually after puberty. The main pathogenesis behind DDD is a mutation in the keratin 5 gene. Here, we present a case of 51‐year‐old female presenting as asymptomatic brownish‐black lesions arranged in a reticular pattern involving flexural sites. The clinical and histopathological findings are consistent with DDD. Her mother, brother, son, and daughter also had similar lesions. The patient was counseled about the prognosis and treatment options of the disease. |
| format | Article |
| id | doaj-art-61e3d4c798364bcbb97e188b8ca63f60 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-61e3d4c798364bcbb97e188b8ca63f602025-08-21T03:19:25ZengWileyClinical Case Reports2050-09042025-07-01137n/an/a10.1002/ccr3.70643Unraveling Dowling–Degos Disease: A Rare Skin DisorderMahesh Mathur0Neha Thakur1Supriya Paudel2Sambidha Karki3Sandhya Regmi4Nabita Bhattarai5Department of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalDepartment of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalDepartment of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalDepartment of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalDepartment of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalDepartment of Dermatology College of Medical Sciences Teaching Hospital Bharatpur NepalABSTRACT Dowling–Degos disease (DDD) is a rare genodermatosis characterized by brown to black macules distributed symmetrically in the axilla, groin, elbow, face, neck, and trunk. It is more common in women, usually after puberty. The main pathogenesis behind DDD is a mutation in the keratin 5 gene. Here, we present a case of 51‐year‐old female presenting as asymptomatic brownish‐black lesions arranged in a reticular pattern involving flexural sites. The clinical and histopathological findings are consistent with DDD. Her mother, brother, son, and daughter also had similar lesions. The patient was counseled about the prognosis and treatment options of the disease.https://doi.org/10.1002/ccr3.70643Dowling–Degos diseasegenodermatosishistopathologykeratin 5 gene |
| spellingShingle | Mahesh Mathur Neha Thakur Supriya Paudel Sambidha Karki Sandhya Regmi Nabita Bhattarai Unraveling Dowling–Degos Disease: A Rare Skin Disorder Clinical Case Reports Dowling–Degos disease genodermatosis histopathology keratin 5 gene |
| title | Unraveling Dowling–Degos Disease: A Rare Skin Disorder |
| title_full | Unraveling Dowling–Degos Disease: A Rare Skin Disorder |
| title_fullStr | Unraveling Dowling–Degos Disease: A Rare Skin Disorder |
| title_full_unstemmed | Unraveling Dowling–Degos Disease: A Rare Skin Disorder |
| title_short | Unraveling Dowling–Degos Disease: A Rare Skin Disorder |
| title_sort | unraveling dowling degos disease a rare skin disorder |
| topic | Dowling–Degos disease genodermatosis histopathology keratin 5 gene |
| url | https://doi.org/10.1002/ccr3.70643 |
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