β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome
<p><strong>Background:</strong> β2microglobulin is recognized as a tumor marker for different purposes in malignant hematopathies of lymphoid lineage; however, there is no history of its use in the Cienfuegos province.<br /><strong>Objective:</strong> to describe...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2023-03-01
|
| Series: | Medisur |
| Subjects: | |
| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5576 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576896109379584 |
|---|---|
| author | Pedro Javier Sánchez Sánchez Julio Dámaso Fernández Águila Pedro Sánchez Frenes María de Jesús Sánchez Bouza Karelys Díaz Alfonso |
| author_facet | Pedro Javier Sánchez Sánchez Julio Dámaso Fernández Águila Pedro Sánchez Frenes María de Jesús Sánchez Bouza Karelys Díaz Alfonso |
| author_sort | Pedro Javier Sánchez Sánchez |
| collection | DOAJ |
| description | <p><strong>Background:</strong> β2microglobulin is recognized as a tumor marker for different purposes in malignant hematopathies of lymphoid lineage; however, there is no history of its use in the Cienfuegos province.<br /><strong>Objective:</strong> to describe the sociodemographic and clinical characteristics and the distribution of serum β2microglobulin levels in patients with chronic lymphoproliferative syndrome and their relationship with clinical stages and response to first-line treatment. <br /><strong>Methods:</strong> cross-sectional descriptive observational study. The series was made up of all adult patients (universe 50) recently diagnosed (without starting specific antitumor therapy) of multiple myeloma, chronic lymphoid leukemia, non-Hodgkin lymphoma and Hodgkin lymphoma, admitted to the Hematology Service of the Dr. Gustavo Aldereguìa Lima General University Hospital, during the year 2020. The information was obtained through documentary review of medical records and laboratory tests. The analyzed variables were: sex, age, skin color, β2microglobulin levels, type of disease, clinical stages and response to treatment. <br /><strong>Results:</strong> 84% of the series presented high levels of the analyte, more accentuated in myeloma. A relationship was found between the stratified levels of β2microglobulin with the clinical stages and the response to first-line treatment.<br /><strong>Conclusions:</strong> the sociodemographic characteristics and the clinical variables observed do not differ substantially from what was reported. The distribution of β2microglobulin levels is suggestive of a direct relationship between clinical stages and an inverse relationship with response to treatment.</p> |
| format | Article |
| id | doaj-art-61e05801b5ca4a3fa1b4881697cae051 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2023-03-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-61e05801b5ca4a3fa1b4881697cae0512025-01-30T21:29:00ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2023-03-012123553662279β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndromePedro Javier Sánchez Sánchez0Julio Dámaso Fernández Águila1Pedro Sánchez Frenes2María de Jesús Sánchez Bouza3Karelys Díaz Alfonso4Hospital General Universitario Dr. Gustavo Aldereguía Lima. Cienfuegos. Cuba.Hospital General Universitario Dr. Gustavo Aldereguía Lima. Cienfuegos. Cuba.Banco de Sangre Provincial de Cienfuegos. Cuba.Universidad de Ciencias Médicas de Cienfuegos. Cuba.Hospital Pediátrico Universitario Paquito González Cueto. Cienfuegos. Cuba.<p><strong>Background:</strong> β2microglobulin is recognized as a tumor marker for different purposes in malignant hematopathies of lymphoid lineage; however, there is no history of its use in the Cienfuegos province.<br /><strong>Objective:</strong> to describe the sociodemographic and clinical characteristics and the distribution of serum β2microglobulin levels in patients with chronic lymphoproliferative syndrome and their relationship with clinical stages and response to first-line treatment. <br /><strong>Methods:</strong> cross-sectional descriptive observational study. The series was made up of all adult patients (universe 50) recently diagnosed (without starting specific antitumor therapy) of multiple myeloma, chronic lymphoid leukemia, non-Hodgkin lymphoma and Hodgkin lymphoma, admitted to the Hematology Service of the Dr. Gustavo Aldereguìa Lima General University Hospital, during the year 2020. The information was obtained through documentary review of medical records and laboratory tests. The analyzed variables were: sex, age, skin color, β2microglobulin levels, type of disease, clinical stages and response to treatment. <br /><strong>Results:</strong> 84% of the series presented high levels of the analyte, more accentuated in myeloma. A relationship was found between the stratified levels of β2microglobulin with the clinical stages and the response to first-line treatment.<br /><strong>Conclusions:</strong> the sociodemographic characteristics and the clinical variables observed do not differ substantially from what was reported. The distribution of β2microglobulin levels is suggestive of a direct relationship between clinical stages and an inverse relationship with response to treatment.</p>http://medisur.sld.cu/index.php/medisur/article/view/5576trastornos linfoproliferativosbiomarcadores de tumor |
| spellingShingle | Pedro Javier Sánchez Sánchez Julio Dámaso Fernández Águila Pedro Sánchez Frenes María de Jesús Sánchez Bouza Karelys Díaz Alfonso β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome Medisur trastornos linfoproliferativos biomarcadores de tumor |
| title | β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| title_full | β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| title_fullStr | β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| title_full_unstemmed | β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| title_short | β2microglobulin levels, clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| title_sort | β2microglobulin levels clinical and sociodemographic variables in patients with recently diagnosed chronic lymphoproliferative syndrome |
| topic | trastornos linfoproliferativos biomarcadores de tumor |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5576 |
| work_keys_str_mv | AT pedrojaviersanchezsanchez b2microglobulinlevelsclinicalandsociodemographicvariablesinpatientswithrecentlydiagnosedchroniclymphoproliferativesyndrome AT juliodamasofernandezaguila b2microglobulinlevelsclinicalandsociodemographicvariablesinpatientswithrecentlydiagnosedchroniclymphoproliferativesyndrome AT pedrosanchezfrenes b2microglobulinlevelsclinicalandsociodemographicvariablesinpatientswithrecentlydiagnosedchroniclymphoproliferativesyndrome AT mariadejesussanchezbouza b2microglobulinlevelsclinicalandsociodemographicvariablesinpatientswithrecentlydiagnosedchroniclymphoproliferativesyndrome AT karelysdiazalfonso b2microglobulinlevelsclinicalandsociodemographicvariablesinpatientswithrecentlydiagnosedchroniclymphoproliferativesyndrome |