Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies
We have designed and built ultrasound imaging-guided HIFU ablative device for preclinical studies on small animals. Before this device is used to treat animals, ex vivo tissue studies were necessary to determine the location and extent of necrotic lesions created inside tissue samples by HIFU beams...
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| Format: | Article |
| Language: | English |
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Institute of Fundamental Technological Research Polish Academy of Sciences
2021-06-01
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| Series: | Archives of Acoustics |
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| Online Access: | https://acoustics.ippt.pan.pl/index.php/aa/article/view/2900 |
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| author | Łukasz FURA Wojciech DERA Cezary DZIEKOŃSKI Maciej ŚWIĄTKIEWICZ Tamara KUJAWSKA |
| author_facet | Łukasz FURA Wojciech DERA Cezary DZIEKOŃSKI Maciej ŚWIĄTKIEWICZ Tamara KUJAWSKA |
| author_sort | Łukasz FURA |
| collection | DOAJ |
| description | We have designed and built ultrasound imaging-guided HIFU ablative device for preclinical studies on small animals. Before this device is used to treat animals, ex vivo tissue studies were necessary to determine the location and extent of necrotic lesions created inside tissue samples by HIFU beams depending on their acoustic properties. This will allow to plan the beam movement trajectory and the distance and time intervals between exposures leading to necrosis covering the entire treated volume without damaging the surrounding tissues. This is crucial for therapy safety. The objective of this study was to assess the impact of sonication parameters on the size of necrotic lesions formed by HIFU beams generated by 64-mm bowl-shaped transducer used, operating at 1.08 MHz or 3.21 MHz. Multiple necrotic lesions were created in pork loin samples at 12.6-mm depth below tissue surface during 3-s exposure to HIFU beams with fixed duty-cycle and varied pulse-duration or fixed pulse-duration and varied duty-cycle, propagated in two-layer media: water-tissue. After exposures, the necrotic lesions were visualized using magnetic resonance imaging and optical imaging (photos) after sectioning the samples. Quantitative analysis of the obtained results allowed to select the optimal sonication and beam movement parameters to support planning of effective therapy. |
| format | Article |
| id | doaj-art-61decd7dbfaf45d3a095e79b76e4a268 |
| institution | Kabale University |
| issn | 0137-5075 2300-262X |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Institute of Fundamental Technological Research Polish Academy of Sciences |
| record_format | Article |
| series | Archives of Acoustics |
| spelling | doaj-art-61decd7dbfaf45d3a095e79b76e4a2682025-08-20T03:56:22ZengInstitute of Fundamental Technological Research Polish Academy of SciencesArchives of Acoustics0137-50752300-262X2021-06-0146210.24425/aoa.2021.136573Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical StudiesŁukasz FURA0Wojciech DERA1Cezary DZIEKOŃSKI2Maciej ŚWIĄTKIEWICZ3Tamara KUJAWSKA4Institute of Fundamental Technological Research Polish Academy of SciencesInstitute of Fundamental Technological Research of the Polish Academy of SciencesInstitute of Fundamental Technological Research of the Polish Academy of SciencesMossakowski Medical Research Centre of the Polish Academy of SciencesInstitute of Fundamental Technological Research Polish Academy of SciencesWe have designed and built ultrasound imaging-guided HIFU ablative device for preclinical studies on small animals. Before this device is used to treat animals, ex vivo tissue studies were necessary to determine the location and extent of necrotic lesions created inside tissue samples by HIFU beams depending on their acoustic properties. This will allow to plan the beam movement trajectory and the distance and time intervals between exposures leading to necrosis covering the entire treated volume without damaging the surrounding tissues. This is crucial for therapy safety. The objective of this study was to assess the impact of sonication parameters on the size of necrotic lesions formed by HIFU beams generated by 64-mm bowl-shaped transducer used, operating at 1.08 MHz or 3.21 MHz. Multiple necrotic lesions were created in pork loin samples at 12.6-mm depth below tissue surface during 3-s exposure to HIFU beams with fixed duty-cycle and varied pulse-duration or fixed pulse-duration and varied duty-cycle, propagated in two-layer media: water-tissue. After exposures, the necrotic lesions were visualized using magnetic resonance imaging and optical imaging (photos) after sectioning the samples. Quantitative analysis of the obtained results allowed to select the optimal sonication and beam movement parameters to support planning of effective therapy.https://acoustics.ippt.pan.pl/index.php/aa/article/view/2900automated ultrasound imaging-guided HIFU ablation systemex vivo tissueultrasonic exposure parametersextent of necrotic lesions |
| spellingShingle | Łukasz FURA Wojciech DERA Cezary DZIEKOŃSKI Maciej ŚWIĄTKIEWICZ Tamara KUJAWSKA Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies Archives of Acoustics automated ultrasound imaging-guided HIFU ablation system ex vivo tissue ultrasonic exposure parameters extent of necrotic lesions |
| title | Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies |
| title_full | Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies |
| title_fullStr | Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies |
| title_full_unstemmed | Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies |
| title_short | Experimental Assessment of the Impact of Sonication Parameters on Necrotic Lesions Induced in Tissues by HIFU Ablative Device for Preclinical Studies |
| title_sort | experimental assessment of the impact of sonication parameters on necrotic lesions induced in tissues by hifu ablative device for preclinical studies |
| topic | automated ultrasound imaging-guided HIFU ablation system ex vivo tissue ultrasonic exposure parameters extent of necrotic lesions |
| url | https://acoustics.ippt.pan.pl/index.php/aa/article/view/2900 |
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