The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome
Objective. To evaluate the efficacy and safety of the combination of metformin and methotrexate (MTX) versus MTX monotherapy in treating psoriasis in patients with metabolic syndrome. Materials and Methods. A prospective clinical trial was conducted using metformin and MTX to treat psoriasis patient...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/9838867 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557305495814144 |
|---|---|
| author | Huynh Thi Xuan Tam Luong Nguyen Dac Thuy Ngo Minh Vinh Tran Ngoc Anh Bui Thi Van |
| author_facet | Huynh Thi Xuan Tam Luong Nguyen Dac Thuy Ngo Minh Vinh Tran Ngoc Anh Bui Thi Van |
| author_sort | Huynh Thi Xuan Tam |
| collection | DOAJ |
| description | Objective. To evaluate the efficacy and safety of the combination of metformin and methotrexate (MTX) versus MTX monotherapy in treating psoriasis in patients with metabolic syndrome. Materials and Methods. A prospective clinical trial was conducted using metformin and MTX to treat psoriasis patients with metabolic syndrome. A treatment group of 35 psoriasis patients with metabolic syndrome was treated with MTX and metformin. A control group of 31 psoriasis patients with metabolic syndrome was treated with MTX only. Results. Patients treated with the combined regimen showed measured improvement in disease status compared to those treated with MTX monotherapy. The Psoriasis Area and Severity Index (PASI) scores of psoriasis patients with metabolic syndrome using the metformin and MTX combination were significantly lower than those treated with MTX only p<0.05. The combination treatment group also showed a significant decrease in blood sugar and triglyceride levels after 3 months p<0.05. However, there were no significant differences in subclinical indexes between the treatment and control groups. Conclusion. In this treatment sample, a combination of metformin and MTX in psoriasis patients with metabolic syndrome showed positive responses and no serious side effects. |
| format | Article |
| id | doaj-art-61dc91c4ec3f416b9c467dbb9f20fbd6 |
| institution | Kabale University |
| issn | 1687-6113 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-61dc91c4ec3f416b9c467dbb9f20fbd62025-02-03T05:19:26ZengWileyDermatology Research and Practice1687-61132022-01-01202210.1155/2022/9838867The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic SyndromeHuynh Thi Xuan Tam0Luong Nguyen Dac Thuy1Ngo Minh Vinh2Tran Ngoc Anh3Bui Thi Van4Pham Ngoc Thach University of MedicineUniversity of Medicine and PharmacyPham Ngoc Thach University of MedicinePham Ngoc Thach University of MedicineScientific Institute of Clinical Medicine and Pharmacy 108Objective. To evaluate the efficacy and safety of the combination of metformin and methotrexate (MTX) versus MTX monotherapy in treating psoriasis in patients with metabolic syndrome. Materials and Methods. A prospective clinical trial was conducted using metformin and MTX to treat psoriasis patients with metabolic syndrome. A treatment group of 35 psoriasis patients with metabolic syndrome was treated with MTX and metformin. A control group of 31 psoriasis patients with metabolic syndrome was treated with MTX only. Results. Patients treated with the combined regimen showed measured improvement in disease status compared to those treated with MTX monotherapy. The Psoriasis Area and Severity Index (PASI) scores of psoriasis patients with metabolic syndrome using the metformin and MTX combination were significantly lower than those treated with MTX only p<0.05. The combination treatment group also showed a significant decrease in blood sugar and triglyceride levels after 3 months p<0.05. However, there were no significant differences in subclinical indexes between the treatment and control groups. Conclusion. In this treatment sample, a combination of metformin and MTX in psoriasis patients with metabolic syndrome showed positive responses and no serious side effects.http://dx.doi.org/10.1155/2022/9838867 |
| spellingShingle | Huynh Thi Xuan Tam Luong Nguyen Dac Thuy Ngo Minh Vinh Tran Ngoc Anh Bui Thi Van The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome Dermatology Research and Practice |
| title | The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome |
| title_full | The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome |
| title_fullStr | The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome |
| title_full_unstemmed | The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome |
| title_short | The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome |
| title_sort | combined use of metformin and methotrexate in psoriasis patients with metabolic syndrome |
| url | http://dx.doi.org/10.1155/2022/9838867 |
| work_keys_str_mv | AT huynhthixuantam thecombineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT luongnguyendacthuy thecombineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT ngominhvinh thecombineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT tranngocanh thecombineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT buithivan thecombineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT huynhthixuantam combineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT luongnguyendacthuy combineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT ngominhvinh combineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT tranngocanh combineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome AT buithivan combineduseofmetforminandmethotrexateinpsoriasispatientswithmetabolicsyndrome |