Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics
Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China. Interestingly, our previous work has found that R. crenulate extract (RCE) could significantly improve the pathology associated with dextran sulfate sodium-induced colitis. Thus, the current resear...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-07-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250176 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850147340811239424 |
|---|---|
| author | Yu Peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan Xu Jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu Yuanqing Gao Hongxun Tao |
| author_facet | Yu Peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan Xu Jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu Yuanqing Gao Hongxun Tao |
| author_sort | Yu Peng |
| collection | DOAJ |
| description | Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China. Interestingly, our previous work has found that R. crenulate extract (RCE) could significantly improve the pathology associated with dextran sulfate sodium-induced colitis. Thus, the current research aims to reveal the pharmacodynamic material basis of RCE, as well as its mechanism against colitis. The chemical characterization of RCE was performed by UHPLC-HR-MS, through which a total of 88 constituents were identified. Meanwhile, our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds. The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis. The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism, steroid hormone biosynthesis and bile acid metabolism. Correspondingly, RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism. |
| format | Article |
| id | doaj-art-61dc8f74ccf444f092b61ddb307b9625 |
| institution | OA Journals |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-61dc8f74ccf444f092b61ddb307b96252025-08-20T02:27:35ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011342116213110.26599/FSHW.2022.9250176Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomicsYu Peng0Xiaoao Xiao1Tingting Ji2Xinyuan Wang3Yixuan Xu4Jianbo Xiao5Hui Cao6Zhiyong Chen7Huifan Liu8Yuanqing Gao9Hongxun Tao10Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Analytical Chemistry and Food Science, Faculty of Science, University of Vigo, Vigo 36310, SpainShaanxi Academy of Traditional Chinese Medicine, Xi'an 710003, ChinaGuangdong Key Laboratory of Science and Technology of Lingnan Specialty Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510550, ChinaKey Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, ChinaSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaRhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China. Interestingly, our previous work has found that R. crenulate extract (RCE) could significantly improve the pathology associated with dextran sulfate sodium-induced colitis. Thus, the current research aims to reveal the pharmacodynamic material basis of RCE, as well as its mechanism against colitis. The chemical characterization of RCE was performed by UHPLC-HR-MS, through which a total of 88 constituents were identified. Meanwhile, our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds. The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis. The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism, steroid hormone biosynthesis and bile acid metabolism. Correspondingly, RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.https://www.sciopen.com/article/10.26599/FSHW.2022.9250176rhodiola crenulatecolitischemical characterizationplasma pharmacochemistrymetabolomics |
| spellingShingle | Yu Peng Xiaoao Xiao Tingting Ji Xinyuan Wang Yixuan Xu Jianbo Xiao Hui Cao Zhiyong Chen Huifan Liu Yuanqing Gao Hongxun Tao Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics Food Science and Human Wellness rhodiola crenulate colitis chemical characterization plasma pharmacochemistry metabolomics |
| title | Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics |
| title_full | Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics |
| title_fullStr | Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics |
| title_full_unstemmed | Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics |
| title_short | Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics |
| title_sort | reveal the pharmacodynamic substances and mechanism of an edible medicinal plant rhodiola crenulate in dss induced colitis through plasma pharmacochemistry and metabolomics |
| topic | rhodiola crenulate colitis chemical characterization plasma pharmacochemistry metabolomics |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250176 |
| work_keys_str_mv | AT yupeng revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT xiaoaoxiao revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT tingtingji revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT xinyuanwang revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT yixuanxu revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT jianboxiao revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT huicao revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT zhiyongchen revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT huifanliu revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT yuanqinggao revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics AT hongxuntao revealthepharmacodynamicsubstancesandmechanismofanediblemedicinalplantrhodiolacrenulateindssinducedcolitisthroughplasmapharmacochemistryandmetabolomics |